Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 1/20 | 0.52 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.47 |
| ▸ | SSTR5 | P35346 | 10/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | APP | P05067 | 1/20 | 0.43 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.43 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11367266 | 0.93 | OPRM1 (0.60) | OPRM1SIGMAR1MEN1KMT2ANPSR1 | |
| SCHEMBL3232374 | 0.90 | OPRM1 (0.52) | OPRM1SIGMAR1MEN1KMT2ANPSR1 | |
| SCHEMBL3007287 | 0.89 | OPRM1 (0.47) | OPRM1SIGMAR1MEN1KMT2ANPSR1 | |
| SCHEMBL2255568 | 0.84 | SSTR5 (0.49) | OPRM1SIGMAR1MEN1KMT2ANPSR1 | |
| SCHEMBL3233651 | 0.83 | OPRM1 (0.49) | OPRM1SIGMAR1MEN1KMT2ANPSR1 | |
| SCHEMBL11363005 | 0.83 | OPRM1 (0.49) | OPRM1SIGMAR1MEN1KMT2ANPSR1 | |
| SCHEMBL11372478 | 0.82 | SSTR5 (0.50) | OPRM1SIGMAR1MEN1KMT2ANPSR1 | |
| SCHEMBL11367505 | 0.82 | MEN1 (0.52) | MEN1KMT2ANPSR1ALDH1A1ALOX15 | |
| SCHEMBL3229133 | 0.81 | SIGMAR1 (0.51) | OPRM1SIGMAR1MEN1KMT2ANPSR1 | |
| SCHEMBL11363329 | 0.81 | MEN1 (0.53) | OPRM1SIGMAR1MEN1KMT2ANPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4255432-A | ANTIHYPERTENSIVE AGENTS, ANTIHISTAMINES, BRONCHODILATOR AGENTS, ANTIVASOSPASTIC AGENTS | SYNTEX (U.S.A.) INC. (US) | 1981-03-10 | — | — | US | disclosed |
| US-4244961-A | 1-Oxa-3,8-diazaspiro[4.5]decan-2-ones antihypertensive agents | SYNTEX (U.S.A.) INC. (US) | 1981-01-13 | — | — | US | disclosed |