Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 3/20 | 0.41 |
| ▸ | CHRNA7 | P36544 | 3/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | KCNN2 | Q9H2S1 | 4/20 | 0.39 |
| ▸ | KCNN3 | Q9UGI6 | 4/20 | 0.39 |
| ▸ | KCNN1 | Q92952 | 2/20 | 0.39 |
| ▸ | SLC18A2 | Q05940 | 1/20 | 0.38 |
| ▸ | RAD52 | P43351 | 1/20 | 0.37 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
| ▸ | DRD1 | P21728 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11220353 | 1.00 | MAOA (0.41) | MAOACHRNA7TSHRKCNN2KCNN3 | |
| SCHEMBL11220867 | 0.89 | HTR2C (0.49) | DRD2DRD1 | |
| SCHEMBL11229746 | 0.87 | HTR2A (0.46) | MAOACHRNA7 | |
| SCHEMBL11221051 | 0.83 | SLC18A2 (0.39) | MAOATSHRKCNN2KCNN3KCNN1 | |
| SCHEMBL11232884 | 0.80 | HTR2C (0.33) | RAD52DRD2DRD1 | |
| SCHEMBL11219797 | 0.80 | ATM (0.39) | RAD52DRD2DRD1 | |
| SCHEMBL11221677 | 0.77 | SLC18A2 (0.39) | MAOATSHRKCNN2KCNN3KCNN1 | |
| SCHEMBL11220976 | 0.77 | KDM4E (0.43) | CHRNA7DRD2DRD1 | |
| SCHEMBL11222256 | 0.76 | KCNN2 (0.38) | MAOATSHRKCNN2KCNN3KCNN1 | |
| SCHEMBL11218519 | 0.75 | PARP1 (0.41) | TSHRDRD2DRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4251526-A | HYPOTENSIVE AGENTS AND ANTIPSYCHOTIC | PHARMACIA & UPJOHN COMPANY | 1981-02-17 | — | — | US | disclosed |
| US-4247553-A | HYPOTENSIVE AGENTS, ANTIDEPRESSANTS | THE UPJOHN COMPANY (US) | 1981-01-27 | — | — | US | disclosed |