Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMO | O15229 | 5/20 | 0.59 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.53 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.53 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.53 |
| ▸ | ALOX5AP | P20292 | 5/20 | 0.49 |
| ▸ | FEN1 | P39748 | 5/20 | 0.49 |
| ▸ | DHFR | P00374 | 1/20 | 0.47 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.47 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.47 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.47 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.47 |
| ▸ | AHR | P35869 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | IKBKB | O14920 | 1/20 | 0.42 |
| ▸ | KIF20B | Q96Q89 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2322762 | 0.79 | SLC6A2 (0.49) | SLC6A2SLC6A4SLC6A3ALOX5APFEN1 | |
| SCHEMBL15912858 | 0.78 | ALOX5AP (0.51) | KMOSLC6A2SLC6A4SLC6A3ALOX5AP | |
| SCHEMBL27736107 | 0.76 | IDO1 (0.51) | SLC6A2SLC6A4SLC6A3ALOX5APFEN1 | |
| SCHEMBL5318865 | 0.76 | KDM1A (0.50) | ALOX5APFEN1DHFRADORA1 | |
| SCHEMBL21266740 | 0.76 | PIK3CD (0.66) | SLC6A2SLC6A4SLC6A3ALOX5APFEN1 | |
| SCHEMBL12925931 | 0.76 | ALOX5AP (0.46) | ALOX5APFEN1NPC1RAB9AKDM4E | |
| SCHEMBL6701547 | 0.74 | PIK3CG (0.51) | ALOX5APFEN1PIK3CGADORA1 | |
| SCHEMBL40268 | 0.74 | NPC1 (0.51) | ALOX5APFEN1NPC1MAPT | |
| SCHEMBL14742330 | 0.74 | KMO (1.00) | KMODHFRAHRNPC1RAB9A | |
| SCHEMBL15912919 | 0.74 | ALOX5AP (0.69) | ALOX5APFEN1PIK3CDPIK3CAPIK3CB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4293552-A | Novel 1-(mono-o-substituted benzoyl)-3-(substituted pyrazinyl) ureas | ELI LILLY AND COMPANY (US) | 1981-10-06 | — | — | US | disclosed |
| US-4160834-A | INSECTICIDES | ELI LILLY AND COMPANY (US) | 1979-07-10 | — | — | US | disclosed |
| US-4083977-A | Novel insecticidal 1-(substituted benzoyl)-3-(substituted pyrazinyl)ureas | ELI LILLY AND COMPANY (US) | 1978-04-11 | — | — | US | disclosed |