Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5AP | P20292 | 6/20 | 0.69 |
| ▸ | FEN1 | P39748 | 7/20 | 0.65 |
| ▸ | MGAM | O43451 | 1/20 | 0.58 |
| ▸ | GAA | P10253 | 1/20 | 0.58 |
| ▸ | SI | P14410 | 1/20 | 0.58 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.58 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.44 |
| ▸ | CTSA | P10619 | 1/20 | 0.44 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.43 |
| ▸ | SYK | P43405 | 1/20 | 0.41 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.41 |
| ▸ | PLAU | P00749 | 1/20 | 0.41 |
| ▸ | LTA4H | P09960 | 1/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.40 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.40 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.40 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.40 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.40 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15913213 | 0.81 | ALOX5AP (1.00) | ALOX5APFEN1MGAMGAASI | |
| SCHEMBL15913079 | 0.79 | FEN1 (1.00) | ALOX5APFEN1 | |
| SCHEMBL15912858 | 0.76 | ALOX5AP (0.51) | ALOX5APFEN1MAP4K4PIK3CDPIK3CA | |
| SCHEMBL11189337 | 0.75 | LTA4H (0.49) | ALOX5APFEN1MGAMGAASI | |
| SCHEMBL4194593 | 0.74 | SYK (0.63) | MGAMGAASIMGAM2SYK | |
| SCHEMBL11372102 | 0.74 | KMO (0.59) | ALOX5APFEN1PIK3CDPIK3CAPIK3CB | |
| SCHEMBL27772805 | 0.74 | PTGER1 (0.60) | MGAMGAASIMGAM2CTSA | |
| SCHEMBL15912845 | 0.73 | FEN1 (1.00) | ALOX5APFEN1 | |
| SCHEMBL8611382 | 0.72 | ALOX5AP (0.47) | ALOX5APFEN1MGAMGAASI | |
| SCHEMBL17589345 | 0.71 | MRGPRX4 (0.66) | MGAMGAASIMGAM2PTGER1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2951169-B1 | FLAP MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2019-08-28 | — | — | EP | disclosed |
| US-9926333-B2 | Flap modulators | JANSSEN PHARMACEUTICA NV (BE) | 2018-03-27 | — | — | US | disclosed |
| US-20170327514-A1 | FLAP MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2017-11-16 | — | — | US | disclosed |
| US-9732093-B2 | FLAP modulators | JANSSEN PHARMACEUTICA NV (BE) | 2017-08-15 | — | — | US | disclosed |
| US-20150368270-A1 | FLAP MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2015-12-24 | — | — | US | disclosed |
| EP-2951169-A1 | FLAP MODULATORS | Janssen Pharmaceutica, N.V. (BE) | 2015-12-09 | — | — | EP | disclosed |
| US-20150252008-A1 | FLAP MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2015-09-10 | — | — | US | disclosed |
| US-9073876-B2 | Flap modulators | JANSSEN PHARMACEUTICA NV (BE) | 2015-07-07 | — | — | US | disclosed |
| WO-2014121040-A1 | FLAP MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2014-08-07 | — | — | WO | disclosed |
| US-20140221310-A1 | FLAP MODULATORS | JANSSEN PHARMACEUTICA NV (US) | 2014-08-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170327514-A1 | FLAP MODULATORS | FEN1, PGF, TBXA2R | ALOX5AP 70/4885FEN1 1/4885MGAM 2709/4885 |
| US-20140221310-A1 | FLAP MODULATORS | FEN1, PGF, PTGIS | ALOX5AP 61/4885FEN1 1/4885MGAM 2741/4885 |
| US-20150368270-A1 | FLAP MODULATORS | FEN1, PGF, TBXA2R | ALOX5AP 70/4885FEN1 1/4885MGAM 2709/4885 |
| US-20150252008-A1 | FLAP MODULATORS | FEN1, PGF, PTGIS | ALOX5AP 61/4885FEN1 1/4885MGAM 2741/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.