Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 15/20 | 0.57 |
| ▸ | KDR | P35968 | 4/20 | 0.44 |
| ▸ | AXL | P30530 | 1/20 | 0.43 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.42 |
| ▸ | BRAF | P15056 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1137671 | 0.87 | MET (0.43) | METKDRBRAF | |
| Trifluoroacetic Acid SCHEMBL1137637 | 0.83 | MET (0.41) | METKDRBRAF | |
| SCHEMBL3006744 | 0.81 | MET (0.69) | METKDRAXLFFAR1 | |
| SCHEMBL2997276 | 0.81 | MET (0.69) | METKDRAXLFFAR1 | |
| SCHEMBL1137256 | 0.81 | MET (0.69) | METKDRAXLFFAR1 | |
| SCHEMBL1137330 | 0.80 | MET (0.73) | METKDRAXLBRAF | |
| SCHEMBL1137278 | 0.77 | MET (0.69) | METKDRAXLFFAR1 | |
| SCHEMBL1137118 | 0.77 | MET (0.69) | METKDRAXLFFAR1 | |
| SCHEMBL5174786 | 0.77 | MET (0.72) | METKDRAXLBRAF | |
| SCHEMBL1136952 | 0.76 | MET (0.82) | METKDRAXLFFAR1BRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7989477-B2 | Monocyclic heterocycles as kinase inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2011-08-02 | — | — | US | disclosed |
| EP-1737451-B1 | MONOCYCLIC HETEROCYCLES AS KINASE INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2011-02-23 | — | — | EP | disclosed |