Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 13/20 | 0.43 |
| ▸ | BRAF | P15056 | 2/20 | 0.42 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.40 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
| ▸ | TEK | Q02763 | 1/20 | 0.38 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.38 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.38 |
| ▸ | ALOX5AP | P20292 | 2/20 | 0.37 |
| ▸ | FEN1 | P39748 | 2/20 | 0.37 |
| ▸ | GCK | P35557 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL1137637 | 0.96 | MET (0.41) | METBRAFMAPK14NTRK1KDR | |
| SCHEMBL1137269 | 0.88 | MET (0.44) | METBRAFMAPK14NTRK1KDR | |
| SCHEMBL1137252 | 0.87 | MET (0.57) | METBRAFKDR | |
| SCHEMBL1137672 | 0.81 | MET (0.52) | METBRAFMAPK14NTRK1KDR | |
| SCHEMBL3003006 | 0.81 | MET (0.52) | METBRAFMAPK14NTRK1KDR | |
| Trifluoroacetic Acid SCHEMBL1137638 | 0.77 | MET (0.48) | METBRAFMAPK14NTRK1KDR | |
| Trifluoroacetic Acid SCHEMBL3013148 | 0.77 | MET (0.48) | METBRAFMAPK14NTRK1KDR | |
| SCHEMBL1137217 | 0.77 | MET (0.52) | METBRAFMAPK14 | |
| SCHEMBL1137271 | 0.76 | MET (0.51) | METBRAFMAPK14NTRK1KDR | |
| SCHEMBL1137254 | 0.76 | MET (0.59) | METBRAFMAPK14NTRK1KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7989477-B2 | Monocyclic heterocycles as kinase inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2011-08-02 | — | — | US | disclosed |
| EP-1737451-B1 | MONOCYCLIC HETEROCYCLES AS KINASE INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2011-02-23 | — | — | EP | disclosed |