Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR1 | P21554 | 1/20 | 0.44 |
| ▸ | GCGR | P47871 | 1/20 | 0.43 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.43 |
| ▸ | PCTP | Q9UKL6 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 6/20 | 0.43 |
| ▸ | RAB9A | P51151 | 6/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.43 |
| ▸ | SMO | Q99835 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | GSK3B | P49841 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11371270 | 0.94 | SMO (0.47) | DYRK1APCTPNPC1RAB9ACYP1A2 | |
| SCHEMBL11379838 | 0.94 | CNR1 (0.46) | CNR1DYRK1APCTPNPC1RAB9A | |
| SCHEMBL11384812 | 0.93 | SMO (0.47) | PCTPNPC1RAB9ASMN1; SMN2CYP1A2 | |
| SCHEMBL7628324 | 0.92 | PCTP (0.42) | DYRK1APCTPNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL11370506 | 0.92 | GAA (0.42) | DYRK1APCTPNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL11373838 | 0.90 | POLB (0.43) | DYRK1APCTPNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL11374776 | 0.90 | PCTP (0.43) | DYRK1APCTPNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL8667778 | 0.90 | GHSR (0.51) | CNR1GCGRNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL11388831 | 0.89 | GCGR (0.45) | CNR1GCGRDYRK1APCTPNPC1 | |
| SCHEMBL11525837 | 0.88 | CNR1 (0.42) | CNR1NPC1RAB9ASMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4293552-A | Novel 1-(mono-o-substituted benzoyl)-3-(substituted pyrazinyl) ureas | ELI LILLY AND COMPANY (US) | 1981-10-06 | — | — | US | claimed |
| US-4293552-A | Novel 1-(mono-o-substituted benzoyl)-3-(substituted pyrazinyl) ureas | ELI LILLY AND COMPANY (US) | 1981-10-06 | — | — | US | disclosed |