Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.42 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.42 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.42 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.42 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.42 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.42 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.42 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.42 |
| ▸ | PPIB | P23284 | 1/20 | 0.40 |
| ▸ | HTR2A | P28223 | 2/20 | 0.39 |
| ▸ | NPY5R | Q15761 | 2/20 | 0.37 |
| ▸ | CASP3 | P42574 | 1/20 | 0.36 |
| ▸ | CA12 | O43570 | 1/20 | 0.36 |
| ▸ | CA9 | Q16790 | 1/20 | 0.36 |
| ▸ | ABCC9 | O60706 | 2/20 | 0.35 |
| ▸ | ABCC8 | Q09428 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11155942 | 0.75 | PPIB (0.42) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| Hydrochloric Acid SCHEMBL11150119 | 0.73 | MAPT (0.45) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL1464737 | 0.73 | BACE1 (0.55) | — | |
| SCHEMBL1464738 | 0.73 | BACE1 (0.55) | — | |
| SCHEMBL7269382 | 0.72 | MAPT (0.61) | MALT1HTR2A | |
| SCHEMBL9876471 | 0.72 | KDM4E (0.64) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL10334515 | 0.71 | HDAC3 (0.45) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL13167658 | 0.71 | PPIB (0.43) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL2471424 | 0.71 | MALT1 (0.43) | MALT1CASP3ABCC9CYP1A2CYP2D6 | |
| SCHEMBL11248037 | 0.71 | HDAC3 (0.43) | HDAC3HDAC4HDAC1HDAC7HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4284644-A | Spirobenzofuranone compounds | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1981-08-18 | — | — | US | disclosed |
| EP-0018830-A2 | Spirobenzofuranones, their production and pharmaceutical compositions containing them | Takeda Chemical Industries, Ltd. (JP) | 1980-11-12 | — | — | EP | disclosed |