SCHEMBL11380823

SCHEMBL11380823

O=C(CC(Br)C(=O)NCc1ccccc1)NCc1ccccc1

nearest known ligand 0.54

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
GAA P10253 1/20 0.54
KMT2A Q03164 5/20 0.54
MEN1 O00255 3/20 0.54
HPGD P15428 3/20 0.54
L3MBTL1 Q9Y468 1/20 0.51
PLA2G1B P04054 1/20 0.50
ATG4B Q9Y4P1 1/20 0.50
MCL1 Q07820 1/20 0.50
MMP8 P22894 1/20 0.50
POLB P06746 1/20 0.49
PKM P14618 1/20 0.49
ALDH1A1 P00352 3/20 0.49
MAPT P10636 1/20 0.49
RAB9A P51151 1/20 0.49
HTT P42858 1/20 0.49
LMNA P02545 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9979005 0.84 GAA (0.59) GAAKMT2AMEN1HPGDMCL1
SCHEMBL8514567 0.83 KMT2A (0.53) GAAKMT2AMEN1MMP8ALDH1A1
SCHEMBL526281 0.83 KMT2A (0.53) GAAKMT2AMEN1HPGDL3MBTL1
SCHEMBL526555 0.83 KMT2A (0.53) GAAKMT2AMEN1HPGDL3MBTL1
SCHEMBL9979326 0.83 GAA (0.58) GAAKMT2AMEN1HPGDMCL1
SCHEMBL23754579 0.81 KMT2A (0.55) GAAKMT2AMEN1MMP8POLB
SCHEMBL2936657 0.81 KMT2A (0.55) GAAKMT2AMEN1MMP8POLB
SCHEMBL29828465 0.81 KMT2A (0.63) GAAKMT2AMEN1HPGDL3MBTL1
SCHEMBL15610313 0.80 KMT2A (0.57) GAAKMT2AMEN1HPGDMMP8
SCHEMBL8568653 0.80 MMP8 (0.51) GAAKMT2AMEN1L3MBTL1MMP8

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4288373-A HERBICIDES STAUFFER CHEMICAL COMPANY (US) 1981-09-08 US disclosed
US-4259484-A PREEMERGENCE AND POSTEMERGENCE STAUFFER CHEMICAL COMPANY (US) 1981-03-31 US disclosed
US-4224053-A Bis-substituted succinamides and their utility as herbicides STAUFFER CHEMICAL COMPANY (US) 1980-09-23 US disclosed
US-4163660-A Bis-substituted succinamides and their utility as herbicides STAUFFER CHEMICAL COMPANY (US) 1979-08-07 US disclosed
US-4143070-A POSTEMERGENCE AND PREEMERGENCE STAUFFER CHEMICAL COMPANY (US) 1979-03-06 US disclosed
US-4056524-A BIS-SUBSTITUTED SUCCINAMIDES AND THEIR UTILITY AS HERBICIDES STAUFFER CHEMICAL COMPANY (US) 1977-11-01 US disclosed