Known targets — ChEMBL curated mechanism
ABL1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB2AGTR1BCL2BCL2A1BCL2L1BCL2L10BCL2L2BCRBRAFCHRM1CHRNA10CHRNA9DRD1DRD2DRD3DRD4DRD5EGFRF2FLT1FLT4GCKGHSRGNRHRGRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BHTR1AHTR1BHTR1DHTR2AHTR2CHTR3AIDH2KDRKITMAOBMCL1MTTPPP4HBPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PIKFYVEROCK1ROCK2SLC18A2SLC6A2SLC6A3SLC6A4TACR1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8gyrAgyrBparCparEpol
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 20/20 | 0.68 |
| ▸ | CYP2C9 | P11712 | 20/20 | 0.68 |
| ▸ | CYP2D6 | P10635 | 10/20 | 0.68 |
| ▸ | CYP2C19 | P33261 | 8/20 | 0.60 |
| ▸ | CYP1A2 | P05177 | 7/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1138350 | 0.96 | CYP3A4 (0.72) | CYP3A4CYP2C9CYP2D6CYP2C19CYP1A2 | |
| SCHEMBL4591614 | 0.90 | CYP3A4 (0.75) | CYP3A4CYP2C9CYP2D6CYP2C19CYP1A2 | |
| SCHEMBL1381723 | 0.89 | CYP3A4 (0.71) | CYP3A4CYP2C9CYP2D6CYP2C19CYP1A2 | |
| SCHEMBL6923311 | 0.89 | CYP3A4 (0.71) | CYP3A4CYP2C9CYP2D6CYP2C19CYP1A2 | |
| Linaprazan SCHEMBL1138430 | 0.85 | CYP3A4 (0.93) | CYP3A4CYP2C9CYP2D6CYP2C19CYP1A2 | |
| SCHEMBL4591548 | 0.85 | CYP3A4 (0.76) | CYP3A4CYP2C9CYP2D6CYP2C19CYP1A2 | |
| SCHEMBL3274128 | 0.85 | CYP3A4 (0.76) | CYP3A4CYP2C9CYP2D6CYP2C19CYP1A2 | |
| SCHEMBL6922991 | 0.84 | CYP3A4 (0.83) | CYP3A4CYP2C9CYP2D6CYP2C19CYP1A2 | |
| SCHEMBL1381726 | 0.83 | CYP3A4 (0.68) | CYP3A4CYP2C9CYP2D6CYP2C19CYP1A2 | |
| SCHEMBL6923313 | 0.83 | CYP3A4 (0.68) | CYP3A4CYP2C9CYP2D6CYP2C19CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1697360-B1 | NOVEL CRYSTALLINE FORMS OF 2, 3 DIMETHYL-8- (2, 6-DIMETHYLBENZYLAMINO) -N-HYDROXYETHYL-IMIDAZO 1, 2-A PYRIDINE-6-CARBOXAMIDE MESYLATE SALT. | ASTRAZENECA AB (SE) | 2011-02-23 | — | — | EP | claimed |
| US-7459463-B2 | Crystalline forms of 2,3-dimethyl-8-(2,6-dimethylbenzylamino)-N-hydroxyethyl-imidazo[1,2-a] pyridine-6-carboxamide mesylate salt | ASTRAZENECA AB (SE) | 2008-12-02 | — | — | US | claimed |
| JP-2007514744-A | — | — | 2007-06-07 | — | — | JP | claimed |
| US-20070112021-A1 | Novel crystalline forms of 2,3-dimethyl-8-(2,6-dimethylbenzylamino)-n-hydroxyethyl- imidazo [1,2-a] pyridine-6-carboxamide mesylate salt | TRAZENECA AB (SE) | 2007-05-17 | — | — | US | claimed |
| EP-1697360-A1 | NOVEL CRYSTALLINE FORMS OF 2, 3 DIMETHYL-8- (2, 6-DIMETHYLBENZYLAMINO) -N-HYDROXYETHYL-IMIDAZO 1, 2-A PYRIDINE-6-CARBOXAMIDE MESYLATE SALT. | AstraZeneca AB (SE) | 2006-09-06 | — | — | EP | claimed |
| EP-1073657-B1 | IMIDAZO PYRIDINE DERIVATIVES WHICH INHIBIT GASTRIC ACID SECRETION | ASTRAZENECA AB (SE) | 2005-12-07 | — | — | EP | claimed |
| WO-2005058895-A1 | NOVEL CRYSTALLINE FORMS OF 2, 3 DIMETHYL-8- (2, 6-DIMETHYLBENZYLAMINO) -N-HYDROXYETHYL-IMIDAZO [1, 2-A] PYRIDINE-6-CARBOXAMIDE MESYLATE SALT. | ASTRAZENECA AB (SE) | 2005-06-30 | — | — | WO | claimed |
| CN-1894246-B | Novel crystalline forms of 2,3-dimethyl-8-(2,6-dimethylbenzylamino)-n-hydroxyethyl-imidazo[1,2-a]pyridine-6-carboxamide mesylate salt | ASTRAZENECA AB | 2011-06-22 | — | — | CN | disclosed |
| EP-1697360-B1 | NOVEL CRYSTALLINE FORMS OF 2, 3 DIMETHYL-8- (2, 6-DIMETHYLBENZYLAMINO) -N-HYDROXYETHYL-IMIDAZO 1, 2-A PYRIDINE-6-CARBOXAMIDE MESYLATE SALT. | ASTRAZENECA AB (SE) | 2011-02-23 | — | — | EP | disclosed |
| EP-1697360-B1 | NOVEL CRYSTALLINE FORMS OF 2, 3 DIMETHYL-8- (2, 6-DIMETHYLBENZYLAMINO) -N-HYDROXYETHYL-IMIDAZO 1, 2-A PYRIDINE-6-CARBOXAMIDE MESYLATE SALT. | ASTRAZENECA AB (SE) | 2011-02-23 | — | — | EP | disclosed |
| US-7459463-B2 | Crystalline forms of 2,3-dimethyl-8-(2,6-dimethylbenzylamino)-N-hydroxyethyl-imidazo[1,2-a] pyridine-6-carboxamide mesylate salt | ASTRAZENECA AB (SE) | 2008-12-02 | — | — | US | disclosed |
| US-7459463-B2 | Crystalline forms of 2,3-dimethyl-8-(2,6-dimethylbenzylamino)-N-hydroxyethyl-imidazo[1,2-a] pyridine-6-carboxamide mesylate salt | ASTRAZENECA AB (SE) | 2008-12-02 | — | — | US | disclosed |
| US-20070112021-A1 | Novel crystalline forms of 2,3-dimethyl-8-(2,6-dimethylbenzylamino)-n-hydroxyethyl- imidazo [1,2-a] pyridine-6-carboxamide mesylate salt | TRAZENECA AB (SE) | 2007-05-17 | — | — | US | disclosed |
| US-20070112021-A1 | Novel crystalline forms of 2,3-dimethyl-8-(2,6-dimethylbenzylamino)-n-hydroxyethyl- imidazo [1,2-a] pyridine-6-carboxamide mesylate salt | TRAZENECA AB (SE) | 2007-05-17 | — | — | US | disclosed |
| CN-1894246-A | Novel crystalline forms of 2,3-dimethyl-8-(2,6-dimethylbenzylamino)-n-hydroxyethyl-imidazo[1,2-a]pyridine-6-carboxamide mesylate salt | ASTRAZENECA AB (SE) | 2007-01-10 | — | — | CN | disclosed |
| EP-1697360-A1 | NOVEL CRYSTALLINE FORMS OF 2, 3 DIMETHYL-8- (2, 6-DIMETHYLBENZYLAMINO) -N-HYDROXYETHYL-IMIDAZO 1, 2-A PYRIDINE-6-CARBOXAMIDE MESYLATE SALT. | AstraZeneca AB (SE) | 2006-09-06 | — | — | EP | disclosed |
| EP-1697360-A1 | NOVEL CRYSTALLINE FORMS OF 2, 3 DIMETHYL-8- (2, 6-DIMETHYLBENZYLAMINO) -N-HYDROXYETHYL-IMIDAZO 1, 2-A PYRIDINE-6-CARBOXAMIDE MESYLATE SALT. | AstraZeneca AB (SE) | 2006-09-06 | — | — | EP | disclosed |
| WO-2005058895-A1 | NOVEL CRYSTALLINE FORMS OF 2, 3 DIMETHYL-8- (2, 6-DIMETHYLBENZYLAMINO) -N-HYDROXYETHYL-IMIDAZO [1, 2-A] PYRIDINE-6-CARBOXAMIDE MESYLATE SALT. | ASTRAZENECA AB (SE) | 2005-06-30 | — | — | WO | disclosed |
| WO-2005058895-A1 | NOVEL CRYSTALLINE FORMS OF 2, 3 DIMETHYL-8- (2, 6-DIMETHYLBENZYLAMINO) -N-HYDROXYETHYL-IMIDAZO [1, 2-A] PYRIDINE-6-CARBOXAMIDE MESYLATE SALT. | ASTRAZENECA AB (SE) | 2005-06-30 | — | — | WO | disclosed |