Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.46 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.39 |
| ▸ | FABP4 | P15090 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11695938 | 0.88 | KDM4E (0.44) | KDM4EALDH1A1GAAPKMHPGD | |
| SCHEMBL11388659 | 0.85 | MEN1 (0.54) | KDM4EALDH1A1GAAHPGD | |
| SCHEMBL11662464 | 0.83 | MEN1 (0.43) | KDM4EPTPN1ALDH1A1GAAHPGD | |
| SCHEMBL11625309 | 0.82 | KDM4E (0.50) | KDM4EALDH1A1GAAPKMHPGD | |
| SCHEMBL11697872 | 0.82 | ALDH1A1 (0.44) | KDM4EALDH1A1GAAHPGDCYP1A2 | |
| SCHEMBL11679136 | 0.79 | ALDH1A1 (0.39) | KDM4EPTPN1ALDH1A1HPGDCYP1A2 | |
| SCHEMBL11624395 | 0.77 | MEN1 (0.55) | KDM4EALDH1A1GAAHPGDCYP1A2 | |
| SCHEMBL11798802 | 0.75 | KDM4E (0.44) | KDM4EPTPN1ALDH1A1GAAPKM | |
| SCHEMBL10779059 | 0.72 | KDM4E (0.53) | KDM4EALDH1A1GAAPKMALOX15 | |
| SCHEMBL11626130 | 0.72 | KDM4E (0.48) | KDM4EALDH1A1GAAHPGDCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4247699-A | REACTION OF AN ISATOIC ANHYDRIDE WITH MALONONITRILE FOLLOWED BY TREATMENT WITH A STRONG ACID OR BASE | PFIZER INC. (US) | 1981-01-27 | — | — | US | disclosed |
| US-4175193-A | INTERMEDIATES FOR 1-OXO-1H-6-ALKOXYPYRIMDO(1,2-A)QUINOLINE-2-CARBOXYLIC ACID AND ESTER ANTIALLERGENS | PFIZER INC. (US) | 1979-11-20 | — | — | US | disclosed |
| US-4066766-A | 1-Oxo-6-substituted pyrimido [1,2-a]quinoline-2-carboxylic acids and derivatives thereof and their use as antiallergy agents | PFIZER INC. (US) | 1978-01-03 | — | — | US | disclosed |
| US-4031217-A | PYRIMIDINE-QUINOLINE COMPOUNDS | PFIZER INC. (US) | 1977-06-21 | — | — | US | disclosed |
| US-4017625-A | Anti-allergic N-(5-tetrazolyl)-1-oxo-1H-6-alkoxypyrimido-[1,2-a]quinoline-2-carboxamides and intermediates therefor | PFIZER INC. (US) | 1977-04-12 | — | — | US | disclosed |
| US-4014881-A | ANTIULCER AGENTS | PFIZER INC. (US) | 1977-03-29 | — | — | US | disclosed |