Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 4/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | JAK2 | O60674 | 1/20 | 0.47 |
| ▸ | JAK1 | P23458 | 1/20 | 0.47 |
| ▸ | TYK2 | P29597 | 1/20 | 0.47 |
| ▸ | JAK3 | P52333 | 1/20 | 0.47 |
| ▸ | MET | P08581 | 1/20 | 0.44 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.44 |
| ▸ | CDK8 | P49336 | 1/20 | 0.44 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.44 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.44 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.44 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.44 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.44 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.44 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.44 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8898020 | 0.86 | HPGD (0.64) | HPGDKDM4EALDH1A1HSD17B10TP53 | |
| SCHEMBL11396639 | 0.83 | HPGD (0.60) | HPGDKDM4EALDH1A1HSD17B10TP53 | |
| SCHEMBL2474844 | 0.81 | HPGD (0.70) | HPGDKDM4EALDH1A1HSD17B10TP53 | |
| SCHEMBL8768975 | 0.81 | KDM4E (0.49) | HPGDKDM4EALDH1A1HSD17B10TP53 | |
| SCHEMBL8482163 | 0.78 | JAK2 (0.53) | HPGDKDM4EALDH1A1HSD17B10TP53 | |
| SCHEMBL11630169 | 0.77 | HPGD (0.42) | HPGDKDM4EALDH1A1HSD17B10TP53 | |
| SCHEMBL10353678 | 0.77 | PDE3B (0.63) | HPGDKDM4EALDH1A1HSD17B10TP53 | |
| SCHEMBL2476874 | 0.74 | HPGD (0.61) | HPGDKDM4EALDH1A1HSD17B10TP53 | |
| SCHEMBL8481283 | 0.73 | PDGFRB (0.59) | HPGDTP53METPDGFRBCDK8 | |
| SCHEMBL11634857 | 0.73 | DCUN1D1 (0.48) | HPGDKDM4EALDH1A1HSD17B10TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4289774-A | Lipid lowering and anti-thrombotic 6-arylpyridazin-3-ones and a process for their preparation | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1981-09-15 | — | — | US | disclosed |
| EP-0010156-A1 | 6-Arylpyridazine-3-ones, pharmaceutical compositions containing them and process for their preparation | MERCK PATENT GmbH (DE) | 1980-04-30 | — | — | EP | disclosed |