Sugi Predict

Sugi Predict / Compounds / SCHEMBL2474844

SCHEMBL2474844

SCHEMBL2474844

O=c1cc(-c2ccccc2)c(-c2ccccc2)n[nH]1

nearest known ligand 0.70

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ HPGD P15428 4/20 0.70
▸ ATM Q13315 1/20 0.55
▸ NPSR1 Q6W5P4 1/20 0.55
▸ PTGS1 P23219 2/20 0.53
▸ CYP1A2 P05177 1/20 0.52
▸ ALDH1A1 P00352 5/20 0.50
▸ KDM4E B2RXH2 3/20 0.50
▸ NPC1 O15118 2/20 0.50
▸ RAB9A P51151 2/20 0.50
▸ TP53 P04637 1/20 0.50
▸ GAA P10253 2/20 0.48
▸ ALPL P05186 1/20 0.48
▸ IDO1 P14902 1/20 0.48
▸ TTK P33981 1/20 0.48
▸ MAPK10 P53779 1/20 0.48
▸ JAK2 O60674 1/20 0.47
▸ JAK1 P23458 1/20 0.47
▸ TYK2 P29597 1/20 0.47
▸ JAK3 P52333 1/20 0.47
▸ ALOX15 P16050 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL391623 0.85 CDK4 (0.57) HPGDNPSR1ALDH1A1KDM4ENPC1
SCHEMBL3946521 0.85 HPGD (0.54) HPGDATMNPSR1PTGS1CYP1A2
SCHEMBL8220437 0.84 HPGD (0.57) HPGDATMNPSR1PTGS1CYP1A2
SCHEMBL11144936 0.82 HPGD (0.64) HPGDATMNPSR1PTGS1CYP1A2
SCHEMBL10288495 0.82 HPGD (0.64) HPGDATMNPSR1PTGS1CYP1A2
SCHEMBL701571 0.82 HPGD (0.64) HPGDATMNPSR1PTGS1CYP1A2
SCHEMBL1550943 0.82 HPGD (1.00) HPGDATMNPSR1PTGS1CYP1A2
SCHEMBL8898020 0.82 HPGD (0.64) HPGDATMNPSR1PTGS1CYP1A2
SCHEMBL11396641 0.81 HPGD (0.57) HPGDATMNPSR1PTGS1CYP1A2
SCHEMBL3946869 0.81 CDK4 (0.59) HPGDALDH1A1NPC1RAB9AGAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 35 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12466805-B2 Pharmaceutical compounds ALMAC DISCOVERY LIMITED (GB) 2025-11-11 — — US disclosed
EP-4103554-A1 SUBSTITUTED 5,6-DIPHENYL-3(2H)-PYRIDAZINONES FOR USE AS FUNGICIDES FMC CORPORATION (US) 2022-12-21 — — EP disclosed
CN-109790146-B Pharmaceutical compounds 阿尔麦克探索有限公司 2022-08-23 — — CN disclosed
EP-3490982-B1 PHARMACEUTICAL COMPOUNDS ALMAC DISCOVERY LTD (GB) 2022-04-20 — — EP disclosed
US-20220002264-A1 PHARMACEUTICAL COMPOUNDS ALMAC DISCOVERY LIMITED (GB) 2022-01-06 — — US disclosed
US-11053213-B2 Pharmaceutical compounds ALMAC DISCOVERY LIMITED (GB) 2021-07-06 — — US disclosed
US-20200385357-A1 SUBSTITUTED PYRIDAZINES AND 1,2,4-TRIAZINES AS PROSTACYCLIN RECEPTOR MODULATORS ARENA PHARMACEUTICALS, INC. 2020-12-10 — — US disclosed
US-10793529-B2 Substituted pyridazines and 1,2,4-triazines as prostacyclin receptor modulators ARENA PHARMACEUTICALS, INC. (US) 2020-10-06 — — US disclosed
US-20190248749-A1 MODULATORS OF THE PROSTACYCLIN (PGI2) RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO ARENA PHARMACEUTICALS, INC. 2019-08-15 — — US disclosed
US-20190233394-A1 PHARMACEUTICAL COMPOUNDS ALMAC DISCOVERY LIMITED (GB) 2019-08-01 — — US disclosed
US-5726162-A FOR CONTROLLING AGRICULTURAL AND MAMMALIAN FUNGAL DISEASES ROHM AND HAAS COMPANY (US) 1998-03-10 — — US disclosed
US-5631254-A RICE; HUMAN INFECTIONS ROHM AND HAAS COMPANY (US) 1997-05-20 — — US disclosed
US-5552409-A PHYTOPATHOGENIC, RICE ROHM AND HAAS COMPANY (US) 1996-09-03 — — US disclosed
EP-0478195-A1 Dihydropyridazinones, pyridazinones and related compounds as fungicides ROHM AND HAAS COMPANY (US) 1992-04-01 — — EP disclosed
EP-0442448-A2 Heterocyclic carboxylic acids and esters Bristol-Myers Squibb Company (US) 1991-08-21 — — EP disclosed
US-4992439-A Pyridazine carboxylic acids and esters BRISTOL-MYERS SQUIBB COMPANY (US) 1991-02-12 — — US disclosed
EP-0088128-A4 ANTIINFLAMMATORY AND ANALGETIC 4-PYRIDYLPYRIDAZIN(2H)-3-ONES. DIAMOND SHAMROCK CORP (US) 1984-04-06 — — EP disclosed
EP-0088128-A1 ANTIINFLAMMATORY AND ANALGETIC 4-PYRIDYLPYRIDAZIN(2H)-3-ONES DIAMOND SHAMROCK CORPORATION (US) 1983-09-14 — — EP disclosed
US-4404203-A AND 6-PHENYL-4,5-DIHYDRO-3/2H/-PYRIDAZINONES WARNER-LAMBERT COMPANY (US) 1983-09-13 — — US disclosed
WO-1983000863-A1 ANTIINFLAMMATORY AND ANALGETIC 4-PYRIDYLPYRIDAZIN(2H)-3-ONES DIAMOND SHAMROCK CORP (US) 1983-03-17 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10793529-B2 Substituted pyridazines and 1,2,4-triazines as prostacyclin receptor modulators PTGIR, PTGIS, TBXA2R HPGD 125/4885ATM 1837/4885NPSR1 612/4885
US-12466805-B2 Pharmaceutical compounds USP19, USP18, UBE2I HPGD 1317/4885ATM 3858/4885NPSR1 2307/4885
US-20190233394-A1 PHARMACEUTICAL COMPOUNDS USP19, USP18, UBE2I HPGD 1317/4885ATM 3858/4885NPSR1 2307/4885
US-20220002264-A1 PHARMACEUTICAL COMPOUNDS USP19, USP18, UBE2I HPGD 1317/4885ATM 3858/4885NPSR1 2307/4885
US-11053213-B2 Pharmaceutical compounds USP19, USP18, UBE2I HPGD 1317/4885ATM 3858/4885NPSR1 2307/4885
US-20190248749-A1 MODULATORS OF THE PROSTACYCLIN (PGI2) RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO PTGIR, PTGIS, PTGER1 HPGD 136/4885ATM 1581/4885NPSR1 872/4885
US-20200385357-A1 SUBSTITUTED PYRIDAZINES AND 1,2,4-TRIAZINES AS PROSTACYCLIN RECEPTOR MODULATORS PTGIR, PTGIS, TBXA2R HPGD 125/4885ATM 1837/4885NPSR1 612/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.