Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.58 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.47 |
| ▸ | RET | P07949 | 1/20 | 0.47 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.47 |
| ▸ | PIM1 | P11309 | 1/20 | 0.47 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.47 |
| ▸ | GSK3B | P49841 | 1/20 | 0.47 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.47 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.47 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.47 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.47 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.47 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.47 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.47 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.47 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1754740 | 0.96 | L3MBTL1 (0.61) | L3MBTL1POLBRAB9ATP53CYP1A2 | |
| SCHEMBL11402365 | 0.85 | NPC1 (0.62) | L3MBTL1RAB9ATP53RETGSK3B | |
| SCHEMBL11402759 | 0.85 | MAPT (0.58) | RAB9ARETMAPTALPLHRH3 | |
| SCHEMBL11402579 | 0.85 | ALPL (0.51) | L3MBTL1POLBRAB9ATP53RET | |
| SCHEMBL7264540 | 0.85 | ALK (0.61) | CYP1A2CHEK1RETPDGFRBPIM1 | |
| SCHEMBL11396914 | 0.83 | JAK2 (0.47) | L3MBTL1POLBRAB9ATP53CYP1A2 | |
| SCHEMBL22130300 | 0.83 | ALPL (0.53) | L3MBTL1POLBRAB9ARETGSK3B | |
| SCHEMBL17016671 | 0.83 | MAPT (0.59) | RAB9ARETMAPTALPLHRH3 | |
| SCHEMBL1752841 | 0.83 | ALPL (0.54) | L3MBTL1POLBRAB9ARETGSK3B | |
| SCHEMBL1753098 | 0.83 | ALPL (0.53) | L3MBTL1POLBRAB9ATP53RET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4289774-A | Lipid lowering and anti-thrombotic 6-arylpyridazin-3-ones and a process for their preparation | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1981-09-15 | — | — | US | disclosed |
| EP-0010156-A1 | 6-Arylpyridazine-3-ones, pharmaceutical compositions containing them and process for their preparation | MERCK PATENT GmbH (DE) | 1980-04-30 | — | — | EP | disclosed |