SCHEMBL11397291

SCHEMBL11397291

CCOCc1nnc(C)n1-c1ccccc1C(=O)O

nearest known ligand 0.49

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
MYC P01106 4/20 0.49
NR4A1 P22736 1/20 0.49
POLB P06746 3/20 0.43
KDM4E B2RXH2 1/20 0.42
ALDH1A1 P00352 1/20 0.41
APEX1 P27695 1/20 0.40
RECQL P46063 1/20 0.40
CTDSP1 Q9GZU7 1/20 0.40
TDP1 Q9NUW8 1/20 0.40
L3MBTL1 Q9Y468 1/20 0.40
SETDB1 Q15047 1/20 0.39
TSHR P16473 2/20 0.38
BRD4 O60885 3/20 0.38
BRD2 P25440 3/20 0.38
BRD3 Q15059 3/20 0.38
SMN1; SMN2 Q16637 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11407032 0.88 MYC (0.47) MYCNR4A1POLBKDM4EALDH1A1
SCHEMBL11407836 0.84 MYC (0.43) MYCNR4A1POLBKDM4EALDH1A1
SCHEMBL11402584 0.83 MYC (0.39) MYCNR4A1POLBKDM4EALDH1A1
SCHEMBL11397192 0.81 MYC (0.54) MYCNR4A1POLBALDH1A1APEX1
Phthalic Acid SCHEMBL45284 0.72 ALDH1A1 (0.64) MYCNR4A1POLBKDM4EALDH1A1
SCHEMBL11398831 0.72 MYC (0.51) MYCNR4A1POLBKDM4EALDH1A1
SCHEMBL11403891 0.72 MYC (0.37) MYCNR4A1TSHR
SCHEMBL11825426 0.71 MYC (0.46) MYCNR4A1POLBALDH1A1TDP1
SCHEMBL19292784 0.71 SETDB1 (0.43) MYCNR4A1SETDB1
SCHEMBL11400787 0.70 MYC (0.50) MYCNR4A1POLBALDH1A1TDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4296239-A Amino-4H-s-triazolo[4,3-a][1,4]benzodiazepines THE UPJOHN COMPANY (US) 1981-10-20 US disclosed
US-4180668-A Piperidino-4H-s-triazolo[4,3-a][1,4]benzodiazepines THE UPJOHN COMPANY (US) 1979-12-25 US disclosed