Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE2A | O00408 | 12/20 | 0.42 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.39 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.39 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.39 |
| ▸ | DAO | P14920 | 1/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.39 |
| ▸ | GCGR | P47871 | 2/20 | 0.37 |
| ▸ | GIPR | P48546 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11395002 | 0.82 | PDE2A (0.46) | PDE2AHSD11B1HCRTR1HCRTR2OPRM1 | |
| SCHEMBL11398466 | 0.78 | CYP2D6 (0.37) | DAO | |
| SCHEMBL11398807 | 0.77 | ALKBH5 (0.39) | PDE2ADAO | |
| SCHEMBL11611483 | 0.74 | TSHR (0.47) | HCRTR1HCRTR2DAO | |
| SCHEMBL11407508 | 0.74 | PTGS1 (0.41) | — | |
| SCHEMBL11408369 | 0.72 | GPR139 (0.35) | — | |
| SCHEMBL11408383 | 0.72 | AKR1C3 (0.37) | PDE2A | |
| SCHEMBL23398944 | 0.70 | DAO (0.35) | DAO | |
| SCHEMBL11402476 | 0.69 | MAPT (0.43) | OPRM1 | |
| SCHEMBL155707 | 0.66 | TSHR (0.58) | PDE2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4288446-A | DIURETICS, SALURETICS, HYPOTENSIVE AGENTS | BAYER AKTIENGESELLSCHAFT (DE) | 1981-09-08 | — | — | US | disclosed |
| US-4081596-A | DIURETIC, SALURETIC, ANTIHYPERTENSIVE, ANTITHROMBOTIC | BAYER AKTIENGESELLSCHAFT (DT) | 1978-03-28 | — | — | US | disclosed |
| US-4045571-A | DIURETICS, SALURETICS, ANTIHYPERTENSIVE AGENTS | BAYER AKTIENGESELLSCHAFT (DT) | 1977-08-30 | — | — | US | disclosed |
| US-4018890-A | Pyrazol-5-one pharmaceutical compositions and methods for effecting diuresis, saluresis and for treating hypertension | BAYER AKTIENGESELLSCHAFT (DT) | 1977-04-19 | — | — | US | disclosed |
| US-4005215-A | DIURETIC | BAYER AKTIENGESELLSCHAFT (DT) | 1977-01-25 | — | — | US | disclosed |
| US-3978077-A | DIURETIC, HYPOTENSIVE, ANTITHROMBOTIC | BAYER AKTIENGESELLSCHAFT (GB) | 1976-08-31 | — | — | US | disclosed |
| US-3957814-A | DIURETICS, SALURETICS, HYPOTENSIVE AGENTS, ANTITHROMBOTIC | BAYER AKTIENGESELLSCHAFT (DT) | 1976-05-18 | — | — | US | disclosed |