Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 2/20 | 0.36 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | CA12 | O43570 | 1/20 | 0.32 |
| ▸ | BRD4 | O60885 | 1/20 | 0.32 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.32 |
| ▸ | CA9 | Q16790 | 1/20 | 0.32 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.32 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.32 |
| ▸ | TYMS | P04818 | 1/20 | 0.32 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15828537 | 0.81 | ALDH1A1 (0.39) | HTR1ADRD2KDM4ECA12BRD4 | |
| SCHEMBL3785969 | 0.70 | HTR1A (0.41) | HTR1ADRD2KDM4EMAPT | |
| SCHEMBL19751542 | 0.67 | ALDH1A1 (0.32) | — | |
| SCHEMBL4999235 | 0.67 | HTR1A (0.38) | HTR1ADRD2KDM4EMAPTCA12 | |
| SCHEMBL4421682 | 0.66 | HTR1A (0.46) | HTR1ADRD2KDM4EMAPTMCL1 | |
| SCHEMBL10967544 | 0.65 | CA12 (0.41) | HTR1ADRD2KDM4ECA12BRD4 | |
| SCHEMBL4357253 | 0.65 | CA12 (0.38) | HTR1ADRD2KDM4ECA12BRD4 | |
| Oxirane SCHEMBL865844 | 0.64 | KDM4E (0.31) | KDM4ETYMS | |
| SCHEMBL5982877 | 0.64 | HTR1A (0.36) | HTR1ADRD2CA12BRD4BRPF1 | |
| SCHEMBL11207376 | 0.63 | HPGD (0.55) | HTR1ADRD2KDM4EMCL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4251534-A | Antihypertensive polyfluorohydroxyisopropyl bicyclic and tricyclic carbostyrils | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1981-02-17 | — | — | US | disclosed |