Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.31 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.31 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.31 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1539497 | 0.81 | TSHR (0.39) | TSHR | |
| SCHEMBL32679671 | 0.80 | TDP1 (0.39) | TSHRTAAR1 | |
| SCHEMBL4574904 | 0.77 | TAAR1 (0.40) | TSHRTAAR1SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL9766273 | 0.77 | ADRB2 (0.36) | TSHRSLC6A2SLC6A4SLC6A3 | |
| SCHEMBL8089657 | 0.77 | CYSLTR2 (0.45) | — | |
| SCHEMBL7146476 | 0.75 | IDO1 (0.38) | TSHRTAAR1 | |
| SCHEMBL147031 | 0.74 | GABRA1 (0.41) | TSHRSLC6A2SLC6A4SLC6A3 | |
| SCHEMBL15654407 | 0.74 | TSHR (0.35) | TSHRSLC6A2SLC6A4SLC6A3 | |
| SCHEMBL6957919 | 0.74 | TSHR (0.35) | TSHR | |
| SCHEMBL15653989 | 0.74 | TSHR (0.35) | TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0025598-A1 | The use of 2-phenyltetralin derivatives, or heterocyclic analogues, in medicine and pharmaceutical compositions containing them | THE WELLCOME FOUNDATION LIMITED (GB) | 1981-03-25 | — | — | EP | disclosed |