Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 3/20 | 0.41 |
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.39 |
| ▸ | KDM5A | P29375 | 1/20 | 0.39 |
| ▸ | RBP4 | P02753 | 1/20 | 0.37 |
| ▸ | AOC1 | P19801 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.37 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.34 |
| ▸ | GABRR1 | P24046 | 1/20 | 0.34 |
| ▸ | GABRR2 | P28476 | 1/20 | 0.34 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28904149 | 0.85 | NPC1 (0.38) | MAPTNPC1RAB9AKMT2ATP53 | |
| SCHEMBL8376540 | 0.74 | DRD2 (0.42) | MAPTNPC1RAB9AALDH1A1TSHR | |
| SCHEMBL28744444 | 0.72 | CYP3A4 (0.60) | KMT2AHRH3CYP3A4SLC7A5ALDH1A1 | |
| SCHEMBL9807751 | 0.71 | CYP19A1 (0.46) | MAPTCYP3A4CYP19A1 | |
| SCHEMBL3273195 | 0.70 | HCAR2 (0.43) | MAPTCYP3A4ALDH1A1TSHRCYP19A1 | |
| SCHEMBL2954704 | 0.70 | MAPT (0.41) | MAPTNPC1RAB9AKMT2ASMN1; SMN2 | |
| SCHEMBL28074714 | 0.69 | MAPT (0.43) | MAPTCYP3A4ALDH1A1CYP19A1 | |
| SCHEMBL11033825 | 0.69 | GAA (0.51) | MAPTNPC1RAB9AKMT2ATP53 | |
| SCHEMBL6558961 | 0.69 | — | — | |
| SCHEMBL2817211 | 0.69 | RBP4 (0.53) | MAPTNPC1RAB9AKMT2ATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4256752-A | ANTIHISTAMINES, ANTISECRETORY AGENTS | DEUTSCHE GOLD- UND SILBER-SCHEIDEANSTALT VORMALS ROESSLER (DE) | 1981-03-17 | — | — | US | disclosed |