Quazinone

Quazinone

SCHEMBL120976

C[C@@H]1C(=O)NC2=Nc3cccc(Cl)c3CN21

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PDE3B Q13370 11/20 1.00
PDE3A Q14432 11/20 1.00
CYP1A2 P05177 2/20 1.00
TSHR P16473 2/20 1.00
LMNA P02545 1/20 1.00
CYP3A4 P08684 1/20 1.00
CYP2D6 P10635 1/20 1.00
BLM P54132 1/20 1.00
CTSD P07339 1/20 0.44
ACHE P22303 1/20 0.39
MEN1 O00255 1/20 0.39
PDE2A O00408 1/20 0.39
KMT2A Q03164 1/20 0.39
P2RY12 Q9H244 1/20 0.39
NOTUM Q6P988 1/20 0.32
ACE P12821 1/20 0.32
MMP13 P45452 1/20 0.32
CRBN Q96SW2 1/20 0.31
HTR2A P28223 1/20 0.31
HTR2C P28335 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Quazinone SCHEMBL2463520 1.00 PDE3B (1.00) PDE3BPDE3ACYP1A2TSHRLMNA
Quazinone SCHEMBL11279841 0.99 PDE3B (0.97) PDE3BPDE3ACYP1A2TSHRLMNA
SCHEMBL11158019 0.85 PDE3B (0.74) PDE3BPDE3ACYP1A2TSHRLMNA
Hydrochloric Acid SCHEMBL11280120 0.84 PDE3B (0.73) PDE3BPDE3ACYP1A2TSHRLMNA
SCHEMBL11400630 0.84 PDE3B (0.73) PDE3BPDE3ACYP1A2TSHRLMNA
SCHEMBL11398470 0.84 PDE3B (0.73) PDE3BPDE3ACYP1A2TSHRLMNA
Hydrochloric Acid SCHEMBL11278036 0.83 PDE3B (0.71) PDE3BPDE3ACYP1A2TSHRLMNA
SCHEMBL11278398 0.82 PDE3B (0.70) PDE3BPDE3ACYP1A2TSHRLMNA
SCHEMBL11279375 0.82 PDE3B (0.69) PDE3BPDE3ACYP1A2TSHRLMNA
Hydrochloric Acid SCHEMBL11388525 0.81 PDE3B (0.68) PDE3BPDE3ACYP1A2TSHRLMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 816 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11903992-B2 Composition comprising lidocaine, l-carnosine and dexpanthenol CELLIX BIO PRIVATE LIMITED (IN) 2024-02-20 US claimed
WO-2023118113-A1 COMPOUNDS TIRAPAZAMINE AND QUAZINONE FOR USE IN THE TREATMENT OF GM2 GANGLIOSIDOSES SOM INNOVATION BIOTECH, S.A. (ES) 2023-06-29 WO claimed
EP-4201403-A1 COMPOUNDS TIRAPAZAMINE AND QUAZINONE FOR USE IN THE TREATMENT OF GM2 GANGLIOSIDOSES Som Innovation Biotech, S.L. (ES) 2023-06-28 EP claimed
CN-217740556-U Four-in-one packaging support, LED lamp bead and full-color display screen 厦门市信达光电科技有限公司 2022-11-04 CN claimed
CN-115207185-A Four-in-one packaging support, LED lamp bead and full-color display screen 厦门市信达光电科技有限公司 2022-10-18 CN claimed
WO-2022190030-A1 A TOPICAL FORMULATION FOR THE TREATMENT OF SKIN DISEASES AVACA PHARMA PRIVATE LIMITED (IN) 2022-09-15 WO claimed
US-20220233629-A1 COMPOSITION COMPRISING LIDOCAINE, L-CARNOSINE AND DEXPANTHENOL CELLIX BIO PRIVATE LIMITED (IN) 2022-07-28 US claimed
WO-2022157587-A1 A COMPOSITION COMPRISING LIDOCAINE, L-CARNOSINE AND DEXPANTHENOL CELLIX BIO PRIVATE LIMITED (IN) 2022-07-28 WO claimed
WO-2022123511-A1 A COMPOSITION COMPRISING FEXOFENADINE CELLIX BIO PRIVATE LIMITED (IN) 2022-06-16 WO claimed
US-20220184052-A1 COMPOSITION COMPRISING FEXOFENADINE CELLIX BIO PRIVATE LIMITED (IN) 2022-06-16 US claimed
US-6337325-B1 IMMUNOSUPRESSANTS, AUTOIMMUNE DISEASES, DERMATITIS, RHINITIS, UVEITIS, ANTIDIABETIC AGENTS, CYSTIC FIBROSIS OR LIVER FIBROSIS HOECHST AKTIENGESELLSCHAFT (DE) 2002-01-08 US claimed
EP-0777482-B1 COMBINED PREPARATION FOR THE THERAPY OF IMMUNE DISEASES HOECHST AG (DE) 2001-11-14 EP claimed
US-6297243-B1 TREATING OSTEOPENIA THAT ACCOMPANIES THE MENOPAUSE NOVO NORDISK A/S (DK) 2001-10-02 US claimed
WO-2001041807-A2 TRANSMUCOSAL COMPOSITION CONTAINING A PHOSPHODIESTERASE INHIBITORS FOR THE TREATMENT OF ERECTILE DYSFUNCTION VIVUS, INC. (US) 2001-06-14 WO claimed
US-6156753-A Local administration of type III phosphodiesterase inhibitors for the treatment of erectile dysfunction VIVUS, INC. (US) 2000-12-05 US claimed
US-6110471-A ADMINISTERING PHOSPHODIESTERASE FOR INHIBITION OF THE CYCLES THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) 2000-08-29 US claimed
EP-1028690-A2 LUTEINISING HORMONE ANTAGONISTS USEFUL FOR TREATMENT OF ESTROGEN DEFICIENCIES, OR AS A CONTRACEPTIVE NOVO NORDISK A/S (DK) 2000-08-23 EP claimed
EP-1012188-A1 COMPOSITION FOR TREATING DIABETES MELLITUS AND OBESITY FORSSMANN, Wolf-Georg, Prof. Dr. (DE) 2000-06-28 EP claimed
WO-1999020223-A2 LUTEINISING HORMONE ANTAGONISTS USEFUL FOR TREATMENT OF ESTROGEN DEFICIENCIES, OR AS A CONTRACEPTIVE NOVO NORDISK A/S (DK) 1999-04-29 WO claimed
WO-1999014239-A1 COMPOSITION FOR TREATING DIABETES MELLITUS AND OBESITY FORSSMANN WOLF GEORG (DE) 1999-03-25 WO claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11903992-B2 Composition comprising lidocaine, l-carnosine and dexpanthenol VNN1, LPL, HMGB1 PDE3B 837/4885PDE3A 296/4885CYP1A2 3874/4885
US-20220233629-A1 COMPOSITION COMPRISING LIDOCAINE, L-CARNOSINE AND DEXPANTHENOL VNN1, LPL, HMGB1 PDE3B 837/4885PDE3A 296/4885CYP1A2 3874/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.