Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | NAMPT | P43490 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | KDM4A | O75164 | 1/20 | 0.35 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.33 |
| ▸ | DRD2 | P14416 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.33 |
| ▸ | GFER | P55789 | 2/20 | 0.33 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22535973 | 0.80 | TDP1 (0.43) | KDM4ELMNANAMPTGAAKDM4A | |
| SCHEMBL22535987 | 0.70 | TDP1 (0.46) | KDM4ELMNANAMPTPOLBMAPK1 | |
| SCHEMBL21484075 | 0.70 | POLB (0.59) | LMNANAMPTPOLBMAPK1ATM | |
| SCHEMBL12906668 | 0.70 | KDM4A (0.43) | KDM4ELMNAGAAKDM4AL3MBTL1 | |
| SCHEMBL22535990 | 0.69 | TDP1 (0.44) | KDM4ELMNANAMPTPOLBMAPK1 | |
| SCHEMBL16491072 | 0.69 | SERPINE1 (0.50) | KDM4ELMNANAMPTPOLBGAA | |
| SCHEMBL8256927 | 0.68 | TSHR (0.50) | NAMPTPOLBMAPK1ATMGAA | |
| SCHEMBL30895753 | 0.68 | POLB (0.43) | KDM4ELMNANAMPTPOLBMAPK1 | |
| SCHEMBL31433016 | 0.67 | MEN1 (0.50) | KDM4ELMNAMAPK1GAATDP1 | |
| SCHEMBL24838193 | 0.67 | AAK1 (0.42) | KDM4EPOLBMAPK1ATMGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0001266-B1 | SUBSTITUTED 2-AMINOMETHYLPHENYL SULFAMATES, PROCESS FOR PREPARING, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME | MERCK & CO. INC. (US) | 1981-04-01 | — | — | EP | disclosed |
| EP-0001266-A1 | Substituted 2-aminomethylphenyl sulfamates, process for preparing, and pharmaceutical compositions containing the same | MERCK & CO. INC. (US) | 1979-04-04 | — | — | EP | disclosed |
| US-4113877-A | DIURETICS, ANTIHYPERTENSIVE AGENTS | MERCK & CO., INC. (US) | 1978-09-12 | — | — | US | disclosed |