Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | KDM4A | O75164 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.40 |
| ▸ | GFER | P55789 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | MAOA | P21397 | 1/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 2/20 | 0.37 |
| ▸ | DRD2 | P14416 | 1/20 | 0.37 |
| ▸ | NAMPT | P43490 | 1/20 | 0.37 |
| ▸ | CA1 | P00915 | 1/20 | 0.37 |
| ▸ | CA12 | O43570 | 1/20 | 0.37 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22535990 | 0.83 | TDP1 (0.44) | TDP1KDM4ELMNAKDM4AMEN1 | |
| SCHEMBL22535987 | 0.81 | TDP1 (0.46) | TDP1KDM4ELMNAKDM4AMEN1 | |
| SCHEMBL11400715 | 0.80 | KDM4E (0.36) | TDP1KDM4ELMNAKDM4AMEN1 | |
| SCHEMBL12906668 | 0.77 | KDM4A (0.43) | KDM4ELMNAKDM4AGAAL3MBTL1 | |
| SCHEMBL31433016 | 0.77 | MEN1 (0.50) | TDP1KDM4ELMNAMEN1GAA | |
| SCHEMBL15700313 | 0.76 | HDAC1 (0.44) | TDP1KDM4AGAAL3MBTL1CA2 | |
| SCHEMBL21484075 | 0.74 | POLB (0.59) | LMNAKDM4AMEN1GAAKMT2A | |
| SCHEMBL30662746 | 0.74 | KDM4E (0.40) | TDP1KDM4ELMNAKDM4AMEN1 | |
| SCHEMBL3180689 | 0.73 | L3MBTL1 (0.61) | TDP1KDM4AGAAL3MBTL1CA2 | |
| SCHEMBL13977598 | 0.73 | KDM4E (0.49) | TDP1KDM4ELMNAKDM4AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230365514-A1 | MACROCYCLIC COMPOUNDS | NOVO NORDISK RESEARCH CENTRE OXFORD LIMITED (GB) | 2023-11-16 | — | — | US | disclosed |
| US-20200399232-A1 | MACROCYCLIC COMPOUNDS | ZIYLO LTD (GB) | 2020-12-24 | — | — | US | disclosed |
| US-10800747-B2 | Macrocyclic compounds | ZIYLO LTD (GB) | 2020-10-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10800747-B2 | Macrocyclic compounds | SLC2A4, GALE, MPI | TDP1 4740/4885KDM4E 2087/4885LMNA 3419/4885 |
| US-20200399232-A1 | MACROCYCLIC COMPOUNDS | SLC2A4, GALE, MPI | TDP1 4740/4885KDM4E 2087/4885LMNA 3419/4885 |
| US-20230365514-A1 | MACROCYCLIC COMPOUNDS | SLC2A4, GALE, MPI | TDP1 4740/4885KDM4E 2087/4885LMNA 3419/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.