Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 6/20 | 0.44 |
| ▸ | GABRA5 | P31644 | 6/20 | 0.44 |
| ▸ | GABRA2 | P47869 | 6/20 | 0.44 |
| ▸ | GABRB2 | P47870 | 5/20 | 0.44 |
| ▸ | GABRA3 | P34903 | 5/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 3/20 | 0.40 |
| ▸ | TLR8 | Q9NR97 | 2/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.32 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.32 |
| ▸ | PTAFR | P25105 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | BRD4 | O60885 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | CNR1 | P21554 | 1/20 | 0.31 |
| ▸ | HTR2A | P28223 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11392671 | 0.91 | GABRA1 (0.46) | GABRA1GABRA5GABRA2GABRB2GABRA3 | |
| SCHEMBL11395725 | 0.87 | GABRA5 (0.45) | GABRA1GABRA5GABRA2GABRB2GABRA3 | |
| SCHEMBL11399292 | 0.86 | HPGD (0.54) | GABRA1GABRA5GABRA2GABRB2GABRA3 | |
| SCHEMBL11402690 | 0.83 | HPGD (0.43) | GABRA1GABRA5GABRA2GABRB2GABRA3 | |
| SCHEMBL11402966 | 0.82 | GABRA1 (0.63) | GABRA1GABRA5GABRA2GABRB2GABRA3 | |
| SCHEMBL11398589 | 0.80 | GABRA1 (0.43) | GABRA1GABRA5GABRA2GABRB2GABRA3 | |
| SCHEMBL11401104 | 0.79 | GABRA1 (0.42) | GABRA1GABRA5GABRA2GABRB2GABRA3 | |
| SCHEMBL11398473 | 0.78 | GABRA1 (0.41) | GABRA1GABRA5GABRA2GABRB2GABRA3 | |
| SCHEMBL11398481 | 0.77 | PTAFR (0.42) | GABRA1GABRA5GABRA2GABRB2GABRA3 | |
| SCHEMBL11104545 | 0.77 | GABRA1 (0.73) | GABRA1GABRA5GABRA2GABRB2GABRA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4296239-A | Amino-4H-s-triazolo[4,3-a][1,4]benzodiazepines | THE UPJOHN COMPANY (US) | 1981-10-20 | — | — | US | disclosed |
| US-4180668-A | Piperidino-4H-s-triazolo[4,3-a][1,4]benzodiazepines | THE UPJOHN COMPANY (US) | 1979-12-25 | — | — | US | disclosed |