SCHEMBL1140165

SCHEMBL1140165

NC(=O)Cn1cc(Br)cn1

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 5/20 0.49
LMNA P02545 3/20 0.49
KDM4E B2RXH2 1/20 0.49
HTT P42858 3/20 0.41
ELANE P08246 5/20 0.40
PLAU P00749 4/20 0.40
F2 P00734 1/20 0.40
KLKB1 P03952 1/20 0.40
HSD17B10 Q99714 2/20 0.39
TSHR P16473 1/20 0.39
MAPK1 P28482 1/20 0.39
KMT2A Q03164 1/20 0.39
PDK2 Q15119 1/20 0.39
POLB P06746 1/20 0.38
HPGD P15428 1/20 0.38
SMN1; SMN2 Q16637 2/20 0.37
GAA P10253 1/20 0.37
RAB9A P51151 1/20 0.37
USP2 O75604 1/20 0.37
PKM P14618 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3888920 0.82 ALDH1A1 (0.46) ALDH1A1LMNAKDM4EHTTELANE
SCHEMBL16437820 0.81 ALDH1A1 (0.45) ALDH1A1LMNAKDM4EHTTELANE
SCHEMBL673074 0.78 MAPT (0.42) ALDH1A1LMNAKMT2APDK2PKM
SCHEMBL17605717 0.78 ALDH1A1 (0.47) ALDH1A1LMNAKDM4EHTTELANE
SCHEMBL13102449 0.77 ALPI (0.53) ALDH1A1LMNAHTTKLKB1KMT2A
SCHEMBL17385156 0.77 PDK2 (0.39) ALDH1A1KDM4EPDK2IKBKETBK1
SCHEMBL1140333 0.77 ALDH1A1 (0.46) ALDH1A1LMNAKDM4EHTTELANE
SCHEMBL17605207 0.77 CCNC (0.47) ALDH1A1LMNAKDM4EHTTPDK2
SCHEMBL2554333 0.74 PDK2 (0.37) PDK2IKBKETBK1
SCHEMBL12986210 0.74 PDK2 (0.45) KMT2APDK2IKBKETBK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115976586-B Forward and reverse pulse electrolytic nickel-tungsten alloy solution, preparation method, electroplating method and nickel-tungsten alloy coating 昆山一鼎工业科技有限公司 2025-03-14 CN claimed
CN-115976586-A Positive and negative pulse electrolytic nickel-tungsten alloy solution, preparation method, electroplating method and nickel-tungsten alloy coating 昆山一鼎工业科技有限公司 2023-04-18 CN claimed
CN-115976586-B Forward and reverse pulse electrolytic nickel-tungsten alloy solution, preparation method, electroplating method and nickel-tungsten alloy coating 昆山一鼎工业科技有限公司 2025-03-14 CN disclosed
CN-115976586-A Positive and negative pulse electrolytic nickel-tungsten alloy solution, preparation method, electroplating method and nickel-tungsten alloy coating 昆山一鼎工业科技有限公司 2023-04-18 CN disclosed
EP-2440521-B1 NOVEL CYCLOPENTANE DERIVATIVES HOFFMANN LA ROCHE (CH) 2014-04-30 EP disclosed
CN-102459162-A Novel cyclopentane derivatives HOFFMANN LA ROCHE 2012-05-16 CN disclosed
EP-2440521-A1 NOVEL CYCLOPENTANE DERIVATIVES F. Hoffmann-La Roche AG (CH) 2012-04-18 EP disclosed
US-7893099-B2 Cyclopentane derivatives HOFFMAN-LA ROCHE INC. (US) 2011-02-22 US disclosed
WO-2010142650-A1 NOVEL CYCLOPENTANE DERIVATIVES F. HOFFMANN-LA ROCHE AG (CH) 2010-12-16 WO disclosed
US-20100317647-A1 NOVEL CYCLOPENTANE DERIVATIVES F. HOFFMANN-LA ROCHE AG (CH) 2010-12-16 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100317647-A1 NOVEL CYCLOPENTANE DERIVATIVES TBXA2R, ADORA1, CNR1 ALDH1A1 125/4885LMNA 2364/4885KDM4E 3982/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.