Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.53 |
| ▸ | GAA | P10253 | 3/20 | 0.53 |
| ▸ | APP | P05067 | 2/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.45 |
| ▸ | RAB9A | P51151 | 3/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | TNNI3K | Q59H18 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | GFER | P55789 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.42 |
| ▸ | TP53 | P04637 | 2/20 | 0.42 |
| ▸ | THRB | P10828 | 2/20 | 0.42 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.41 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.41 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.41 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8759346 | 0.86 | APP (0.56) | MAPTTDP1GAAAPPCYP3A4 | |
| SCHEMBL4930598 | 0.85 | CYP3A4 (0.48) | MAPTTDP1GAAAPPCYP3A4 | |
| Hydrochloric Acid SCHEMBL11647101 | 0.84 | MAPT (0.55) | MAPTTDP1GAAAPPCYP3A4 | |
| SCHEMBL8092872 | 0.82 | TDP1 (0.59) | MAPTTDP1GAAAPPCYP3A4 | |
| SCHEMBL4937983 | 0.81 | MAPT (0.61) | MAPTTDP1GAAAPPCYP3A4 | |
| SCHEMBL29454186 | 0.81 | NPC1 (0.44) | MAPTTDP1GAAAPPCYP3A4 | |
| SCHEMBL22232474 | 0.81 | NPC1 (0.44) | MAPTTDP1GAAAPPCYP3A4 | |
| SCHEMBL11789717 | 0.79 | CYP3A4 (0.43) | MAPTTDP1GAAAPPCYP3A4 | |
| SCHEMBL15638708 | 0.79 | ALDH1A1 (0.45) | MAPTTDP1GAAAPPCYP3A4 | |
| SCHEMBL11741492 | 0.78 | NPSR1 (0.49) | MAPTTDP1GAACYP3A4RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4296114-A | 3,4-Dihydro-3-oxopyrido[2,3-b]-pyrazines, compositions and use thereof | FISONS LIMITED (GB) | 1981-10-20 | — | — | US | disclosed |
| EP-0008864-A1 | Pyridopyrazine and quinoxaline derivatives, processes for their preparation, and pharmaceutical compositions containing them | FISONS plc (GB) | 1980-03-19 | — | — | EP | disclosed |