Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDH1 | O75874 | 18/20 | 0.48 |
| ▸ | TIMP3 | P35625 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | ENPP3 | O14638 | 1/20 | 0.44 |
| ▸ | ENTPD3 | O75355 | 1/20 | 0.44 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.44 |
| ▸ | TDP2 | O95551 | 1/20 | 0.44 |
| ▸ | CBX7 | O95931 | 1/20 | 0.44 |
| ▸ | NSD2 | O96028 | 1/20 | 0.44 |
| ▸ | ESR1 | P03372 | 1/20 | 0.44 |
| ▸ | PRKCG | P05129 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | PRKCB | P05771 | 1/20 | 0.44 |
| ▸ | HTR1A | P08908 | 1/20 | 0.44 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | HSPD1 | P10809 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11443911 | 0.95 | IDH1 (0.47) | IDH1TIMP3MEN1ENPP3ENTPD3 | |
| SCHEMBL11431457 | 0.92 | IDH1 (0.55) | IDH1 | |
| SCHEMBL11416598 | 0.90 | CASP6 (0.41) | IDH1TIMP3MEN1ENPP3ENTPD3 | |
| SCHEMBL11512944 | 0.89 | TIMP3 (0.52) | IDH1TIMP3MEN1ENPP3ENTPD3 | |
| SCHEMBL11415433 | 0.88 | TIMP3 (0.59) | IDH1TIMP3MEN1ENPP3ENTPD3 | |
| SCHEMBL11432048 | 0.87 | CASP6 (0.40) | IDH1TIMP3MEN1ENPP3ENTPD3 | |
| SCHEMBL11441871 | 0.87 | HPSE (0.45) | IDH1TIMP3MEN1ENPP3ENTPD3 | |
| SCHEMBL11437296 | 0.84 | MEN1 (0.50) | IDH1MEN1MAPTKDRKMT2A | |
| SCHEMBL11512326 | 0.82 | TIMP3 (0.45) | TIMP3MEN1ENPP3ENTPD3NR1I2 | |
| SCHEMBL11437498 | 0.82 | TIMP3 (0.59) | IDH1TIMP3MEN1ENPP3ENTPD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0008154-A1 | Ureylene phenylene anionic naphthalene-sulfonic acids, their use as complement system inhibitors in a body fluid and process for their preparation | AMERICAN CYANAMID COMPANY (US) | 1980-02-20 | — | — | EP | claimed |
| US-4229370-A | INHIBITORS OF THE COMPLEMENT SYSTEM, IMMUNOLOGY | AMERICAN CYANAMID COMPANY (US) | 1980-10-21 | — | — | US | disclosed |
| US-4215121-A | Pyrazine substituted ureas | MERCK & CO., INC. (US) | 1980-07-29 | — | — | US | disclosed |
| EP-0008154-A1 | Ureylene phenylene anionic naphthalene-sulfonic acids, their use as complement system inhibitors in a body fluid and process for their preparation | AMERICAN CYANAMID COMPANY (US) | 1980-02-20 | — | — | EP | disclosed |
| US-4155930-A | Ureylene phenylene anionic naphthalenesulfonic acids | AMERICAN CYANAMID COMPANY (US) | 1979-05-22 | — | — | US | disclosed |
| US-4144338-A | N-pyrimidinyl-N-dialkylaminoalkyl ureas | MERCK & CO., INC. (US) | 1979-03-13 | — | — | US | disclosed |