Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.58 |
| ▸ | HNF4A | P41235 | 1/20 | 0.46 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.41 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.41 |
| ▸ | AKR1C1 | Q04828 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | FABP4 | P15090 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Acetic Acid SCHEMBL28274416 | 0.92 | ALDH1A1 (0.54) | ALDH1A1MAPK1HNF4ABCAT2HTT | |
| SCHEMBL29356458 | 0.91 | ALDH1A1 (0.68) | ALDH1A1MAPK1HNF4ABCAT2HPGD | |
| SCHEMBL1627501 | 0.91 | ALDH1A1 (0.68) | ALDH1A1MAPK1HNF4ABCAT2HPGD | |
| Water SCHEMBL2804005 | 0.89 | ALDH1A1 (0.65) | ALDH1A1MAPK1HNF4ABCAT2HPGD | |
| SCHEMBL27830861 | 0.89 | ALDH1A1 (0.65) | ALDH1A1MAPK1HNF4ABCAT2HPGD | |
| Bromide SCHEMBL6343986 | 0.87 | ALDH1A1 (0.62) | ALDH1A1MAPK1HNF4AHTTHPGD | |
| Bicarbonate SCHEMBL11403105 | 0.87 | ALDH1A1 (0.42) | ALDH1A1MAPK1HTTHSD17B10KMT2A | |
| Bicarbonate SCHEMBL27489215 | 0.85 | ALDH1A1 (0.81) | ALDH1A1MAPK1HNF4ABCAT2HPGD | |
| SCHEMBL7519292 | 0.83 | ALDH1A1 (0.62) | ALDH1A1MAPK1HNF4AHTTHPGD | |
| Biphenyl SCHEMBL22588637 | 0.80 | ALDH1A1 (0.48) | ALDH1A1MAPK1HNF4AHTTHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4268429-A | Novel flame retardant polycarbonate compositions | GENERAL ELECTRIC COMPANY (US) | 1981-05-19 | — | — | US | disclosed |