SCHEMBL11405992

SCHEMBL11405992

Clc1ccc(N=Cc2ccccc2)c(Cl)c1

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LMNA P02545 4/20 0.49
ALDH1A1 P00352 4/20 0.46
MAPT P10636 4/20 0.46
POLB P06746 3/20 0.46
KDM4E B2RXH2 2/20 0.46
HTT P42858 2/20 0.46
SMN1; SMN2 Q16637 2/20 0.46
L3MBTL1 Q9Y468 2/20 0.46
CYP1A2 P05177 1/20 0.46
HSP90AA1 P07900 1/20 0.46
CYP2C9 P11712 1/20 0.46
CYP2C19 P33261 1/20 0.46
RECQL P46063 1/20 0.46
HPGD P15428 3/20 0.44
MEN1 O00255 2/20 0.44
KMT2A Q03164 2/20 0.44
NPSR1 Q6W5P4 1/20 0.44
CA12 O43570 1/20 0.43
CA1 P00915 1/20 0.43
CA2 P00918 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30374604 1.00 LMNA (0.49) LMNAALDH1A1MAPTPOLBKDM4E
SCHEMBL11405980 1.00 LMNA (0.49) LMNAALDH1A1MAPTPOLBKDM4E
SCHEMBL4972488 0.89 LMNA (0.51) LMNAALDH1A1MAPTPOLBKDM4E
SCHEMBL5650618 0.89 LMNA (0.51) LMNAALDH1A1MAPTPOLBKDM4E
SCHEMBL31502197 0.87 CHRM5 (0.58) LMNAALDH1A1MAPTPOLBKDM4E
SCHEMBL12416697 0.85 CA1 (0.43) LMNAALDH1A1MAPTPOLBKDM4E
SCHEMBL11418273 0.85 CA1 (0.43) LMNAALDH1A1MAPTPOLBKDM4E
SCHEMBL11411085 0.85 PTGS2 (0.45) LMNAALDH1A1MAPTPOLBKDM4E
SCHEMBL11411084 0.85 PTGS2 (0.45) LMNAALDH1A1MAPTPOLBKDM4E
SCHEMBL11410214 0.82 NPC1 (0.48) LMNAALDH1A1MAPTPOLBKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-112409188-B Method for synthesizing N-alkylamine 南京理工大学 2023-05-05 CN disclosed
CN-112409188-A Method for synthesizing N-alkylamine 南京理工大学 2021-02-26 CN disclosed
US-4235929-A TOPICAL ADMINISTRATION OF ANTIINFLAMMATORY AGENT WILLIAM H. RORER, INC. (US) 1980-11-25 US disclosed
US-4230727-A N-BENZYLIDENEANILINE AND DERIVATIVES WILLIAM H. RORER, INC. (US) 1980-10-28 US disclosed
US-4198349-A ANTIINFLAMMATORY, TOPICAL WILLIAM H. RORER, INC. (US) 1980-04-15 US disclosed
US-4187317-A Sunscreen and erythema treating with N-benzylidene anilenes WILLIAM H. RORER, INC. (US) 1980-02-05 US disclosed
US-4176198-A ANTIINFLAMMATORY AGENTS WILLIAM H. RORER, INC. (US) 1979-11-27 US disclosed