Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 8/20 | 0.66 |
| ▸ | PRSS12 | P56730 | 1/20 | 0.53 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.49 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.49 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.49 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.49 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.49 |
| ▸ | NR2E3 | Q9Y5X4 | 4/20 | 0.47 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.45 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.45 |
| ▸ | ITGB7 | P26010 | 1/20 | 0.45 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.44 |
| ▸ | HPSE | Q9Y251 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | BLM | P54132 | 1/20 | 0.43 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.43 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1248994 | 0.89 | DGAT1 (0.73) | DGAT1PRSS12HDAC3HDAC1HDAC2 | |
| SCHEMBL1251104 | 0.86 | DGAT1 (0.79) | DGAT1PRSS12HDAC3HDAC1HDAC8 | |
| SCHEMBL1248588 | 0.85 | DGAT1 (0.67) | DGAT1PRSS12HDAC3HDAC1HDAC2 | |
| SCHEMBL1248779 | 0.83 | DGAT1 (0.74) | DGAT1PRSS12NR2E3ITGB1ITGA4 | |
| SCHEMBL1251539 | 0.81 | DGAT1 (0.84) | DGAT1HDAC3HDAC6NR2E3CHEK2 | |
| SCHEMBL1248774 | 0.81 | DGAT1 (1.00) | DGAT1PRSS12HDAC6NR2E3CHEK2 | |
| SCHEMBL1250312 | 0.80 | DGAT1 (0.79) | DGAT1PRSS12HDAC6NR2E3CHEK2 | |
| SCHEMBL1249930 | 0.79 | DGAT1 (0.85) | DGAT1PRSS12HDAC3HDAC1HDAC8 | |
| SCHEMBL1251452 | 0.79 | DGAT1 (0.80) | DGAT1HDAC3HDAC1HDAC2HDAC8 | |
| SCHEMBL1251547 | 0.79 | DGAT1 (0.84) | DGAT1NR2E3CHEK2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8222248-B2 | Organic compounds | NOVARTIS AG (CH) | 2012-07-17 | — | — | US | disclosed |
| US-20110046133-A1 | ORGANIC COMPOUNDS | NOVARTIS AG (CH) | 2011-02-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110046133-A1 | ORGANIC COMPOUNDS | DGAT1, DGAT2, SOAT1 | DGAT1 1/4885PRSS12 4183/4885HDAC3 882/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.