SCHEMBL11413201

SCHEMBL11413201

COc1cc(N)ccc1N(C)C(C)=O

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.51
TSPO P30536 1/20 0.47
FSCN1 Q16658 1/20 0.44
GAA P10253 4/20 0.43
MAPT P10636 4/20 0.43
HTT P42858 2/20 0.43
TSHR P16473 1/20 0.43
MAPK1 P28482 1/20 0.43
KDM4E B2RXH2 3/20 0.40
SLC9A1 P19634 1/20 0.39
LMNA P02545 3/20 0.39
L3MBTL1 Q9Y468 2/20 0.39
NR4A1 P22736 1/20 0.39
SMN1; SMN2 Q16637 1/20 0.39
USP2 O75604 1/20 0.38
NPSR1 Q6W5P4 1/20 0.37
ADORA2A P29274 1/20 0.37
ADORA2B P29275 1/20 0.37
ADORA1 P30542 1/20 0.37
KDM4C Q9H3R0 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14873023 0.81 TSPO (0.43) ALDH1A1TSPOFSCN1GAAMAPT
SCHEMBL24534995 0.80 TSPO (0.47) TSPOFSCN1MAPTHTTKDM4E
SCHEMBL24535064 0.79 KDM4E (0.43) ALDH1A1TSPOFSCN1GAAHTT
SCHEMBL30828566 0.78 MAPT (0.52) ALDH1A1GAAMAPTHTTTSHR
SCHEMBL224141 0.78 MAPT (0.52) ALDH1A1GAAMAPTHTTTSHR
Acetoacetic Acid SCHEMBL27821165 0.77 ALDH1A1 (0.43) ALDH1A1GAAMAPTHTTTSHR
SCHEMBL15625331 0.77 MAPT (0.50) ALDH1A1GAAMAPTHTTTSHR
Hydrochloric Acid SCHEMBL30828603 0.77 MAPT (0.50) ALDH1A1GAAMAPTHTTTSHR
SCHEMBL736511 0.76 FSCN1 (0.69) ALDH1A1TSPOFSCN1GAAMAPT
SCHEMBL13725182 0.75 ALDH1A1 (0.50) ALDH1A1GAAMAPTHTTTSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4229171-A Process for the preparation of fiber-reactive dyestuffs HOECHST AKTIENGESELLSCHAFT (DE) 1980-10-21 US disclosed