⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5789919 | 0.78 | ALDH1A1 (0.48) | — | |
| SCHEMBL29440483 | 0.78 | ALDH1A1 (0.48) | — | |
| SCHEMBL27783112 | 0.77 | NFE2L2 (0.43) | — | |
| SCHEMBL15516668 | 0.77 | NFE2L2 (0.43) | — | |
| SCHEMBL25403948 | 0.76 | — | — | |
| SCHEMBL114830 | 0.76 | — | — | |
| SCHEMBL9908261 | 0.76 | — | — | |
| SCHEMBL30454177 | 0.76 | — | — | |
| SCHEMBL3071412 | 0.76 | — | — | |
| SCHEMBL29574715 | 0.75 | ALDH1A1 (0.50) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 29 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100105912-A1 | FLUORO-CONTAINING DERIVATIVES OF HYDROGENATED PYRIDO[4,3-b]INDOLES WITH NEUROPROTECTIVE AND COGNITION ENHANCING PROPERTIES, PROCESS FOR PREPARING, AND USE | D2E, LLC (US) | 2010-04-29 | — | — | US | claimed |
| CN-115605474-A | Microbicidal quinoline dihydro- (thiazine) oxazine derivatives | 先正达农作物保护股份公司（CH） | 2023-01-13 | — | — | CN | disclosed |
| CN-105693712-A | TRPV1 antagonists including dihydroxy substituent and uses thereof | 普渡制药公司 | 2016-06-22 | — | — | CN | disclosed |
| CN-102548984-B | The inhibitor of PI3 kinases and/or MTOR | AMGEN INC. (US) | 2015-11-25 | — | — | CN | disclosed |
| CN-102724875-B | Pyrido[3,4-b]indoles and methods of use | MEDIVATION TECHNOLOGIES INC | 2015-05-27 | — | — | CN | disclosed |
| EP-2424859-B1 | INHIBITORS OF PI3 KINASE AND / OR MTOR | AMGEN INC (US) | 2015-04-08 | — | — | EP | disclosed |
| US-8772480-B2 | Inhibitors of PI3 kinase and/or mTOR | AMGEN INC. (US) | 2014-07-08 | — | — | US | disclosed |
| US-8772480-B2 | Inhibitors of PI3 kinase and/or mTOR | AMGEN INC. (US) | 2014-07-08 | — | — | US | disclosed |
| US-8772480-B2 | Inhibitors of PI3 kinase and/or mTOR | AMGEN INC. (US) | 2014-07-08 | — | — | US | disclosed |
| US-20130079303-A1 | Inhibitors of PI3 Kinase and/or mTOR | AMGEN INC. (US) | 2013-03-28 | — | — | US | disclosed |
| WO-2010126895-A1 | INHIBITORS OF PI3 KINASE AND / OR MTOR | AMGEN INC. (US) | 2010-11-04 | — | — | WO | disclosed |
| US-20100273764-A1 | INHIBITORS OF PI3 KINASE AND/OR MTOR | AMGEN INC. (US) | 2010-10-28 | — | — | US | disclosed |
| US-20100273764-A1 | INHIBITORS OF PI3 KINASE AND/OR MTOR | AMGEN INC. (US) | 2010-10-28 | — | — | US | disclosed |
| US-20100273764-A1 | INHIBITORS OF PI3 KINASE AND/OR MTOR | AMGEN INC. (US) | 2010-10-28 | — | — | US | disclosed |
| CN-101868234-A | Fluorinated derivatives of hydrogenated pyrido [4,3-b ] indoles with neuroprotective and cognition enhancing properties, process for their preparation and their use | D2E LLC | 2010-10-20 | — | — | CN | disclosed |
| EP-2194980-A1 | FLUORO-CONTAINING DERIVATIVES OF HYDROGENTED PYRIDOÝ4,3-B¨INDOLES WITH NEUROPROTECTIVE AND COGNITION ENHANCING PROPERTIES, PROCESS FOR PREPARING, AND USE | D2e, Llc (US) | 2010-06-16 | — | — | EP | disclosed |
| US-20100105912-A1 | FLUORO-CONTAINING DERIVATIVES OF HYDROGENATED PYRIDO[4,3-b]INDOLES WITH NEUROPROTECTIVE AND COGNITION ENHANCING PROPERTIES, PROCESS FOR PREPARING, AND USE | D2E, LLC (US) | 2010-04-29 | — | — | US | disclosed |
| US-20100056790-A1 | FLUORO-CONTAINING DERIVATIVES OF HYDROGENATED PYRIDO[4,3-B]INDOLES WITH NEUROPROTECTIVE AND COGNITION ENHANCING PROPERTIES, PROCESS FOR PREPARING, AND USE | D2E, LLC (US) | 2010-03-04 | — | — | US | disclosed |
| US-20090221627-A1 | Fluoro-containing derivatives of hydrogenated pyrido[4,3-b]indoles with neuroprotective and cognition enhancing properties, process for preparing, and use | D2E, LLC | 2009-09-03 | — | — | US | disclosed |
| WO-2009038764-A1 | FLUORO-CONTAINING DERIVATIVES OF HYDROGENTED PYRIDO[4,3-B]INDOLES WITH NEUROPROTECTIVE AND COGNITION ENHANCING PROPERTIES, PROCESS FOR PREPARING, AND USE | D2E, LLC (US) | 2009-03-26 | — | — | WO | disclosed |