Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 10/20 | 0.38 |
| ▸ | BACE1 | P56817 | 1/20 | 0.37 |
| ▸ | DDB1 | Q16531 | 3/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.36 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.36 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.36 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.35 |
| ▸ | SRD5A1 | P18405 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Alonimid SCHEMBL29728701 | 1.00 | CRBN (0.38) | CRBNBACE1DDB1OPRM1OPRK1 | |
| SCHEMBL11844513 | 0.89 | CRBN (0.40) | CRBNBACE1DDB1OPRM1ITGA4 | |
| SCHEMBL11848256 | 0.89 | BACE1 (0.36) | CRBNBACE1DDB1ITGA4MEN1 | |
| Alonimid SCHEMBL8318670 | 0.83 | PGR (0.34) | CRBNOPRM1OPRK1OPRL1ITGA4 | |
| SCHEMBL11841796 | 0.78 | PARP10 (0.39) | CRBNDDB1 | |
| SCHEMBL11847241 | 0.78 | SRD5A1 (0.43) | CRBNSRD5A1 | |
| SCHEMBL11840949 | 0.78 | CRBN (0.40) | CRBNDDB1 | |
| SCHEMBL11069539 | 0.75 | AKR1B1 (0.51) | — | |
| SCHEMBL11841313 | 0.75 | PDE3B (0.46) | — | |
| SCHEMBL11843628 | 0.74 | TDP2 (0.44) | CRBNDDB1MEN1CYP2C9KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 2385 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240238250-A1 | METHOD OF USING PIROMELATINE FOR TREATING PARASOMNIAS ASSOCIATED WITH LOSS OF REM SLEEP ATONIA | NEURIM PHARMACEUTICALS (1991) LTD. (IL) | 2024-07-18 | — | — | US | claimed |
| WO-2024150170-A1 | PIROMELATINE FOR TREATING PARASOMNIAS ASSOCIATED WITH LOSS OF REM SLEEP ATONIA | NEURIM PHARMACEUTICALS (1991) LTD. (IL) | 2024-07-18 | — | — | WO | claimed |
| US-20190275048-A1 | METHOD OF TREATING INSOMNIA | ROSENBERG LEON I (US) | 2019-09-12 | — | — | US | claimed |
| US-9016221-B2 | Surface topographies for non-toxic bioadhesion control | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) | 2015-04-28 | — | — | US | claimed |
| US-8735383-B2 | Glycine transporter-1 inhibitors | AMGEN INC. (US) | 2014-05-27 | — | — | US | claimed |
| US-8268352-B2 | Modified release composition for highly soluble drugs | TORRENT PHARMACEUTICALS LIMITED (IN) | 2012-09-18 | — | — | US | claimed |
| US-8263125-B2 | Dosage form for high dose-high solubility active ingredients that provides for immediate release and modified release of the active ingredients | TORRENT PHARMACEUTICALS LIMITED (IN) | 2012-09-11 | — | — | US | claimed |
| US-20120195985-A1 | GLYCINE TRANSPORTER-1 INHIBITORS | AMGEN INC. (US) | 2012-08-02 | — | — | US | claimed |
| US-20100226943-A1 | SURFACE TOPOGRAPHIES FOR NON-TOXIC BIOADHESION CONTROL | UNIVERSITY OF FLORIDA (US) | 2010-09-09 | — | — | US | claimed |
| CN-101330905-A | Freeze-drying process and products obtained thereby | SCIDOSE LLC (US) | 2008-12-24 | — | — | CN | claimed |
| US-20060018934-A1 | Novel drug delivery system | TORRENT PHARMACEUTICALS LIMITED (IN) | 2006-01-26 | — | — | US | claimed |
| US-20060018933-A1 | Novel drug delivery system | TORRENT PHARMACEUTICALS LIMITED (IN) | 2006-01-26 | — | — | US | claimed |
| EP-1599199-A2 | METHODS FOR TREATING JOINT PAIN OR IMPROVING SLEEP USING AN ESTROGEN AGONIST/ANTAGONIST | Pfizer Products Inc. (US) | 2005-11-30 | — | — | EP | claimed |
| US-20040152713-A1 | Methods for treating joint pain or improving sleep using an estrogen agonist/antagonist | PFIZER INC. | 2004-08-05 | — | — | US | claimed |
| WO-2004064832-A2 | METHODS FOR TREATING JOINT PAIN OR IMPROVING SLEEP USING AN ESTROGEN AGONIST/ANTAGONIST | PFIZER PRODUCTS INC. (US) | 2004-08-05 | — | — | WO | claimed |
| JP-2000511885-A | — | — | 2000-09-12 | — | — | JP | claimed |
| EP-0900086-A4 | ENHANCEMENT OF SLEEP WITH A GROWTH HORMONE SECRETAGOGUE | MERCK & CO INC (US) | 2000-01-12 | — | — | EP | claimed |
| EP-0900086-A1 | ENHANCEMENT OF SLEEP WITH A GROWTH HORMONE SECRETAGOGUE | Merck & Co., Inc. (US) | 1999-03-10 | — | — | EP | claimed |
| WO-1997041879-A1 | ENHANCEMENT OF SLEEP WITH A GROWTH HORMONE SECRETAGOGUE | MERCK & CO., INC. (US) | 1997-11-13 | — | — | WO | claimed |
| US-3985888-A | Methods of inducing sedation using certain spiroalkanone-imides | RICHARDSON-MERRELL INC. (US) | 1976-10-12 | — | — | US | claimed |