SCHEMBL11416622

SCHEMBL11416622

COc1ccc2nc(C)c(C=O)c(O)c2c1

nearest known ligand 0.50

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
TRIM24 O15164 1/20 0.50
TYR P14679 1/20 0.50
TRIM33 Q9UPN9 1/20 0.50
KDM4E B2RXH2 8/20 0.49
ALDH1A1 P00352 4/20 0.49
HSD17B10 Q99714 3/20 0.49
POLB P06746 2/20 0.49
HPGD P15428 2/20 0.49
ERN1 O75460 2/20 0.49
HTT P42858 1/20 0.48
PLA2G2A P14555 1/20 0.47
LMNA P02545 1/20 0.47
TSHR P16473 1/20 0.46
MEN1 O00255 1/20 0.46
KMT2A Q03164 1/20 0.46
MAPT P10636 1/20 0.44
MAPK1 P28482 1/20 0.44
NPSR1 Q6W5P4 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11414734 0.79 ERN1 (0.51) KDM4EALDH1A1HSD17B10ERN1HTT
SCHEMBL15491361 0.78 KDM4E (0.51) KDM4EALDH1A1HSD17B10POLBHPGD
SCHEMBL28242700 0.77 KDM4E (0.49) KDM4EALDH1A1HSD17B10POLBHPGD
SCHEMBL11869454 0.75 DHODH (0.63) KDM4EALDH1A1HSD17B10POLBHPGD
SCHEMBL11416237 0.75 ERN1 (0.76) TRIM24TRIM33KDM4EALDH1A1HSD17B10
SCHEMBL28242706 0.75 KDM4E (0.48) KDM4EALDH1A1HSD17B10POLBHPGD
SCHEMBL15493096 0.75 KDM4E (0.51) KDM4EALDH1A1HSD17B10POLBHPGD
SCHEMBL15486832 0.74 PLA2G2A (0.56) KDM4EALDH1A1HSD17B10POLBHPGD
SCHEMBL6413743 0.74 TRIM24 (0.62) TRIM24TYRTRIM33KDM4EALDH1A1
SCHEMBL28910000 0.73 POLB (0.61) TRIM24TYRTRIM33KDM4EALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4237292-A SHADES OF YELLOW TO RED FOR PLASTICS AND LACQUERS CIBA-GEIGY CORPORATION (US) 1980-12-02 US disclosed
US-4237286-A COLORING PLASTICS AND LACQUERS IN YELLOW TO RED SHADES CIBA-GEIGY CORPORATION (US) 1980-12-02 US disclosed
US-4237293-A COLORFAST SHADES OF YELLOW TO RED FOR PLASTICS AND LACQUERS CIBA-GEIGY CORPORATION (US) 1980-12-02 US disclosed
US-4144258-A ORGANIC PIGMENTS FOR POLYMERS CIBA-GEIGY CORPORATION (US) 1979-03-13 US disclosed
US-4132708-A Metal complexes of azomethines and process for their manufacture CIBA-GEIGY CORPORATION (US) 1979-01-02 US disclosed
US-4111947-A DYES, PLASTICS, LACQUERS CIBA-GEIGY CORPORATION (US) 1978-09-05 US disclosed
US-4065481-A 1:1-Azomethine-metal-complex dyestuffs CIBA-GEIGY CORPORATION (US) 1977-12-27 US disclosed
US-4024132-A Azomethine pigments CIBA-GEIGY CORPORATION (US) 1977-05-17 US disclosed
US-4022770-A COLORING CIBA-GEIGY CORPORATION (US) 1977-05-10 US disclosed
US-4016157-A COLORING PLASTICS AND LACQUERS CIBA-GEIGY CORPORATION (US) 1977-04-05 US disclosed
US-3988323-A PIGMENTS CIBA-GEIGY CORPORATION (US) 1976-10-26 US disclosed
US-3974149-A TONERS CIBA-GEIGY CORPORATION (US) 1976-08-10 US disclosed