Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MME | P08473 | 1/20 | 0.46 |
| ▸ | ECE1 | P42892 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | MMP1 | P03956 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | REN | P00797 | 2/20 | 0.44 |
| ▸ | CTSK | P43235 | 3/20 | 0.43 |
| ▸ | CASP1 | P29466 | 1/20 | 0.43 |
| ▸ | CASP3 | P42574 | 1/20 | 0.43 |
| ▸ | CASP4 | P49662 | 1/20 | 0.43 |
| ▸ | CASP5 | P51878 | 1/20 | 0.43 |
| ▸ | CASP9 | P55211 | 1/20 | 0.43 |
| ▸ | CASP6 | P55212 | 1/20 | 0.43 |
| ▸ | CASP8 | Q14790 | 1/20 | 0.43 |
| ▸ | CASP10 | Q92851 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11419443 | 0.85 | ALDH1A1 (0.63) | MMEALDH1A1THRBCYP2C9CYP2C19 | |
| Hydrochloric Acid SCHEMBL11288976 | 0.84 | MME (0.49) | MMEECE1SMN1; SMN2CTSKCASP1 | |
| SCHEMBL11412332 | 0.84 | CTSK (0.55) | MMP1RENCTSK | |
| SCHEMBL17344010 | 0.81 | ALDH1A1 (0.54) | MMEALDH1A1THRBCYP2C9CYP2C19 | |
| SCHEMBL11424459 | 0.81 | ALDH1A1 (0.58) | MMEALDH1A1THRBCYP2C9CYP2C19 | |
| SCHEMBL24978636 | 0.81 | TACR1 (0.56) | MMEECE1ALDH1A1SMN1; SMN2CTSK | |
| SCHEMBL11409558 | 0.81 | ABCB1 (0.47) | ALDH1A1THRBCYP2C9CYP2C19HSD17B10 | |
| SCHEMBL7046063 | 0.81 | TACR1 (0.56) | MMEECE1ALDH1A1SMN1; SMN2CTSK | |
| SCHEMBL4919347 | 0.80 | MME (0.56) | MMEECE1SMN1; SMN2CTSKCASP1 | |
| SCHEMBL29682481 | 0.80 | MME (0.56) | MMEECE1SMN1; SMN2CTSKCASP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4228184-A | HYPOTENSIVE AGENTS | E. R. SQUIBB & SONS, INC. (US) | 1980-10-14 | — | — | US | disclosed |
| US-4207336-A | AGIOTENSIN RELATED HYPERTENSION | E. R. SQUIBB & SONS, INC. (US) | 1980-06-10 | — | — | US | disclosed |
| US-4207337-A | ESPECIALLY ANGIOTENSIN RELATED HYPERTENSION | E. R. SQUIBB & SONS, INC. (US) | 1980-06-10 | — | — | US | disclosed |
| US-4207342-A | Relieving hypertension with carboxyalkylacylamino acids | E. R. SQUIBB & SONS, INC. (US) | 1980-06-10 | — | — | US | disclosed |
| US-4200649-A | Relieving hypertension with carboxyalkylacylamino acids | E. R. SQUIBB & SONS, INC. (US) | 1980-04-29 | — | — | US | disclosed |
| US-4192882-A | SUBSTITUTED INDOLES FOR RELIEVING ANGIOTENSIN RELATED HYPERTENSION | E. R. SQUIBB & SONS, INC. (US) | 1980-03-11 | — | — | US | disclosed |
| US-4192881-A | RELIEVING ANGIOTENSIN RELATED HYPERTENSION | E. R. SQUIBB & SONS, INC. (US) | 1980-03-11 | — | — | US | disclosed |
| US-4153725-A | ANGIOTENSIN CONVERTING ENZYME INHIBITORS | E. R. SQUIBB & SONS, INC. (US) | 1979-05-08 | — | — | US | disclosed |
| US-4146641-A | ANGIOTENSIN CONVERTING ENZYME INHIBITORS | E. R. SQUIBB & SONS, INC. (US) | 1979-03-27 | — | — | US | disclosed |
| US-4146639-A | ANGIOTENSIN CONVERTING ENZYME INHIBITORS | E. R. SQUIBB & SONS, INC. (US) | 1979-03-27 | — | — | US | disclosed |
| US-4105789-A | Carboxyalkylacylamino acids | E. R. SQUIBB & SONS, INC. (US) | 1978-08-08 | — | — | US | disclosed |