Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | ELANE | P08246 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | GFER | P55789 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11428325 | 0.85 | OPRK1 (0.57) | MEN1KMT2AHPGDPOLB | |
| SCHEMBL11434198 | 0.81 | MEN1 (0.44) | MEN1KMT2AHPGDPOLBGAA | |
| SCHEMBL11425461 | 0.79 | MEN1 (0.51) | MEN1KMT2AHPGDGAAGFER | |
| SCHEMBL513867 | 0.73 | BRD4 (0.42) | MEN1KMT2APOLBALDH1A1CHRNA7 | |
| SCHEMBL30688734 | 0.73 | BRD4 (0.42) | MEN1KMT2APOLBALDH1A1CHRNA7 | |
| SCHEMBL4422153 | 0.72 | HPGD (0.74) | MEN1KMT2AHPGDGAAALDH1A1 | |
| SCHEMBL8526950 | 0.71 | KMT2A (0.41) | MEN1KMT2APOLBGAAALDH1A1 | |
| SCHEMBL6031788 | 0.70 | ENPP2 (0.60) | MEN1KMT2AHPGDPOLBELANE | |
| SCHEMBL14597189 | 0.70 | POLB (0.74) | MEN1KMT2AHPGDPOLBELANE | |
| SCHEMBL5213974 | 0.69 | HPGD (0.70) | MEN1KMT2AHPGDPOLBGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4239684-A | 1,5'-Benzodiazepine-2-ones, pharmaceutical compositions thereof and method of use thereof | KNOLL AG (DE) | 1980-12-16 | — | — | US | disclosed |
| US-RE30293-E | Process for preparing 1,5-benzodiazepine-2-ones | KNOLL A.G. (DE) | 1980-06-03 | — | — | US | disclosed |
| US-4108852-A | Process for preparing 1,5-benzodiazepine-2-ones | KNOLL AG. (DE) | 1978-08-22 | — | — | US | disclosed |