Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | HTT | P42858 | 3/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | HBB | P68871 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 8/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.33 |
| ▸ | RECQL | P46063 | 2/20 | 0.33 |
| ▸ | GSK3B | P49841 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.33 |
| ▸ | APAF1 | O14727 | 1/20 | 0.33 |
| ▸ | TDP2 | O95551 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11638629 | 0.97 | HSD17B10 (0.36) | HSD17B10ALDH1A1HTTPOLBHPGD | |
| SCHEMBL11420110 | 0.91 | ALDH1A1 (0.33) | HSD17B10ALDH1A1HTTPOLBHPGD | |
| SCHEMBL10411385 | 0.84 | HTT (0.36) | HSD17B10ALDH1A1HTTPOLBHPGD | |
| SCHEMBL10382355 | 0.81 | HSD17B10 (0.44) | HSD17B10ALDH1A1HTTPOLBHPGD | |
| SCHEMBL10381886 | 0.80 | ALDH1A1 (0.43) | HSD17B10ALDH1A1HTTPOLBHPGD | |
| SCHEMBL28512628 | 0.73 | MAPT (0.36) | HSD17B10ALDH1A1HTTPOLBHPGD | |
| SCHEMBL68863 | 0.71 | MAPT (0.36) | HSD17B10ALDH1A1POLBHPGDGAA | |
| SCHEMBL4255732 | 0.71 | MAPT (0.36) | HSD17B10ALDH1A1POLBHPGDKDM4E | |
| SCHEMBL13302892 | 0.70 | ACHE (0.39) | HSD17B10ALDH1A1HTTPOLBHPGD | |
| SCHEMBL68578 | 0.70 | ACHE (0.39) | HSD17B10ALDH1A1HTTPOLBHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4198426-A | 2-Substituted-3-methyl-γ-pyrone tricyclic derivatives | AYERST MCKENNA & HARRISON LTD. (CA) | 1980-04-15 | — | — | US | disclosed |
| US-4189490-A | 2-Substituted-3-methyl-γ-pyrone tricyclic derivatives | AYERST MCKENNA & HARRISON LIMITED (CA) | 1980-02-19 | — | — | US | disclosed |
| US-4177284-A | 2-Substituted-3-methyl-γ-pyrone tricvclic derivatives and process therefor | AYERST MCKENNA & HARRISON LTD. (CA) | 1979-12-04 | — | — | US | disclosed |
| US-4105778-A | ANTIALLERGENS, BACTERICIDES, FUNGICIDES | AYERST, MCKENNA & HARRISON, LTD. (CA) | 1978-08-08 | — | — | US | disclosed |
| US-4060619-A | ANTIALLERGY, MICROBIOCIDE | AYERST MCKENNA AND HARRISON LTD. (CA) | 1977-11-29 | — | — | US | disclosed |