Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CD40 | P25942 | 4/20 | 0.72 |
| ▸ | CD40LG | P29965 | 4/20 | 0.72 |
| ▸ | NPC1 | O15118 | 2/20 | 0.51 |
| ▸ | KDR | P35968 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | DUSP3 | P51452 | 2/20 | 0.47 |
| ▸ | PTPN5 | P54829 | 2/20 | 0.47 |
| ▸ | PTPN11 | Q06124 | 2/20 | 0.47 |
| ▸ | CASP6 | P55212 | 1/20 | 0.47 |
| ▸ | TYMS | P04818 | 1/20 | 0.46 |
| ▸ | ACHE | P22303 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 4/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.45 |
| ▸ | MITF | O75030 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | CASP3 | P42574 | 1/20 | 0.45 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.45 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11439166 | 0.89 | CD40 (0.58) | CD40CD40LGNPC1KDRMAPT | |
| SCHEMBL11433131 | 0.87 | CD40 (0.69) | CD40CD40LGNPC1KDRMAPT | |
| SCHEMBL19021224 | 0.85 | CD40 (0.92) | CD40CD40LGNPC1KDRMAPT | |
| SCHEMBL11433859 | 0.84 | CD40 (0.63) | CD40CD40LGNPC1KDRMAPT | |
| SCHEMBL20590980 | 0.84 | CD40 (1.00) | CD40CD40LGNPC1KDRRAB9A | |
| SCHEMBL11342795 | 0.84 | CD40 (0.58) | CD40CD40LGKDRMAPTALDH1A1 | |
| SCHEMBL10907887 | 0.84 | CD40 (0.58) | CD40CD40LGMAPTALDH1A1MEN1 | |
| SCHEMBL11500762 | 0.84 | CD40 (0.53) | CD40CD40LGMAPTCASP6ALDH1A1 | |
| SCHEMBL11423169 | 0.83 | MAPT (0.55) | CD40CD40LGNPC1MAPTRAB9A | |
| SCHEMBL11425171 | 0.83 | HPGD (0.56) | CD40CD40LGNPC1MAPTRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4216166-A | Nitro precursors to amine precursors to ureide inhibitors of connective tissue destruction | AMERICAN CYANAMID COMPANY (US) | 1980-08-05 | — | — | US | disclosed |