Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CD40 | P25942 | 5/20 | 0.92 |
| ▸ | CD40LG | P29965 | 5/20 | 0.92 |
| ▸ | KDR | P35968 | 1/20 | 0.54 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.54 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.54 |
| ▸ | CASP6 | P55212 | 1/20 | 0.54 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.54 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | PARP1 | P09874 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | CASP3 | P42574 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | ACHE | P22303 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.46 |
| ▸ | TYMS | P04818 | 1/20 | 0.44 |
| ▸ | TTR | P02766 | 1/20 | 0.44 |
| ▸ | FABP4 | P15090 | 1/20 | 0.44 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20590980 | 0.96 | CD40 (1.00) | CD40CD40LGKDRDUSP3PTPN5 | |
| SCHEMBL19021223 | 0.91 | CD40 (0.87) | CD40CD40LGKDRDUSP3PTPN5 | |
| SCHEMBL19020655 | 0.89 | CD40 (0.87) | CD40CD40LGKDRDUSP3PTPN5 | |
| SCHEMBL26885664 | 0.87 | CD40 (0.79) | CD40CD40LGKDRDUSP3PTPN5 | |
| SCHEMBL11425089 | 0.85 | CD40 (0.72) | CD40CD40LGKDRDUSP3PTPN5 | |
| SCHEMBL11433131 | 0.85 | CD40 (0.69) | CD40CD40LGKDRDUSP3PTPN5 | |
| SCHEMBL11511725 | 0.85 | CD40 (0.69) | CD40CD40LGKDRDUSP3PTPN5 | |
| SCHEMBL11439481 | 0.84 | CD40 (0.68) | CD40CD40LGKDRDUSP3PTPN5 | |
| SCHEMBL19020654 | 0.83 | CD40 (0.69) | CD40CD40LGCASP6NPC1MAPT | |
| SCHEMBL11797457 | 0.83 | NPC1 (0.66) | CD40CD40LGKDRDUSP3PTPN5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3389781-B1 | INHIBITORS OF TNF SUPERFAMILY COSTIMULATORY INTERACTIONS AND METHODS FOR USES OF THE SAME | UNIV MIAMI (US) | 2021-08-11 | — | — | EP | disclosed |
| US-10562848-B2 | Inhibitors of TNF superfamily costimulatory interactions and methods for uses of the same | UNIVERSITY OF MIAMI (US) | 2020-02-18 | — | — | US | disclosed |
| US-10562848-B2 | Inhibitors of TNF superfamily costimulatory interactions and methods for uses of the same | UNIVERSITY OF MIAMI (US) | 2020-02-18 | — | — | US | disclosed |
| US-20180370909-A1 | INHIBITORS OF TNF SUPERFAMILY COSTIMULATORY INTERACTIONS AND METHODS FOR USES OF THE SAME | UNIVERSITY OF MIAMI (US) | 2018-12-27 | — | — | US | disclosed |
| WO-2017106436-A1 | INHIBITORS OF TNF SUPERFAMILY COSTIMULATORY INTERACTIONS AND METHODS FOR USES OF THE SAME | UNIVERSITY OF MIAMI (US) | 2017-06-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180370909-A1 | INHIBITORS OF TNF SUPERFAMILY COSTIMULATORY INTERACTIONS AND METHODS FOR USES OF THE SAME | CD40, TNFRSF9, TNFRSF1A | CD40 1/4885CD40LG 7/4885KDR 364/4885 |
| US-10562848-B2 | Inhibitors of TNF superfamily costimulatory interactions and methods for uses of the same | CD40, TNFRSF9, TNFRSF1A | CD40 1/4885CD40LG 7/4885KDR 364/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.