Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 1/20 | 0.43 |
| ▸ | MAOB | P27338 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | HTR2C | P28335 | 3/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.40 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | HTR2B | P41595 | 2/20 | 0.39 |
| ▸ | HTR7 | P34969 | 1/20 | 0.39 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7876404 | 0.79 | KCNH2 (0.43) | KCNH2HTR2CTP53KMT2AMEN1 | |
| SCHEMBL16801501 | 0.79 | TP53 (0.41) | HTR2CTP53ALDH1A1HTR2BHTR2A | |
| SCHEMBL16801711 | 0.77 | GSK3B (0.44) | KCNH2HTR2CALDH1A1HTR2ASMN1; SMN2 | |
| SCHEMBL2982905 | 0.75 | IDO1 (0.41) | HTR2CALDH1A1MAPT | |
| SCHEMBL23785707 | 0.75 | IDO1 (0.41) | HTR2CALDH1A1MAPT | |
| Hydrochloric Acid SCHEMBL6249275 | 0.74 | HTR2C (0.41) | HTR2CALDH1A1MAPT | |
| SCHEMBL6642813 | 0.73 | NOS3 (0.48) | MAOAMAOBTP53PDE3BPDE3A | |
| SCHEMBL15730582 | 0.73 | MAOA (0.51) | MAOAMAOBTP53PDE3BPDE3A | |
| SCHEMBL26655574 | 0.72 | HTR2C (0.43) | MAOAMAOBHTR2CALDH1A1HTR2B | |
| SCHEMBL18901276 | 0.72 | MAOA (0.46) | MAOAMAOBTP53PDE3BPDE3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4224333-A | Antihypertensive 2H-indol-2-ones | ROUSSEL UCLAF (FR) | 1980-09-23 | — | — | US | disclosed |