Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 1/20 | 0.50 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.50 |
| ▸ | CASP6 | P55212 | 1/20 | 0.46 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.46 |
| ▸ | CD40 | P25942 | 3/20 | 0.45 |
| ▸ | CD40LG | P29965 | 3/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.44 |
| ▸ | CCR8 | P51685 | 3/20 | 0.44 |
| ▸ | TIMP3 | P35625 | 2/20 | 0.43 |
| ▸ | CA12 | O43570 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | CA9 | Q16790 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 5/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11428212 | 0.91 | AURKB (0.56) | AURKAAURKBCASP6CTDSP1CD40 | |
| SCHEMBL11430982 | 0.88 | HSD17B10 (0.52) | AURKAAURKBHDAC1CCR8TIMP3 | |
| SCHEMBL10909141 | 0.86 | CD40 (0.52) | AURKAAURKBCD40CD40LGCCR8 | |
| SCHEMBL11433078 | 0.86 | AURKB (0.52) | AURKAAURKBCASP6CTDSP1CD40 | |
| SCHEMBL11427718 | 0.86 | HDAC1 (0.46) | AURKAAURKBCASP6CTDSP1CD40 | |
| SCHEMBL11436491 | 0.86 | HDAC1 (0.46) | AURKAAURKBCASP6CTDSP1CD40 | |
| SCHEMBL11341986 | 0.86 | TIMP3 (0.58) | AURKAAURKBCD40CD40LGCCR8 | |
| SCHEMBL11758756 | 0.85 | TIMP3 (0.54) | AURKAAURKBCASP6CTDSP1CD40 | |
| SCHEMBL11441468 | 0.84 | AURKA (0.50) | AURKAAURKBCD40CD40LGTIMP3 | |
| SCHEMBL11425028 | 0.84 | MAPT (0.48) | AURKAAURKBCD40CD40LGTIMP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4216165-A | Amine precursors to ureide inhibitors of connective tissue destruction | AMERICAN CYANAMID COMPANY (US) | 1980-08-05 | — | — | US | disclosed |