SCHEMBL1142985

SCHEMBL1142985

CC(C)(C)CC(=O)COCC1CCCCC1

nearest known ligand 0.38

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
LMNA P02545 1/20 0.38
SLC1A3 P43003 3/20 0.35
SLC1A2 P43004 3/20 0.35
SLC1A1 P43005 3/20 0.35
MEN1 O00255 1/20 0.35
MAPT P10636 1/20 0.35
KMT2A Q03164 1/20 0.35
ATM Q13315 1/20 0.35
NAAA Q02083 1/20 0.33
PARP15 Q460N3 1/20 0.33
PARP10 Q53GL7 1/20 0.33
SPHK1 Q9NYA1 2/20 0.32
EPHX1 P07099 1/20 0.32
HPGD P15428 1/20 0.32
NPSR1 Q6W5P4 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1142910 0.98 LMNA (0.35) LMNASLC1A3SLC1A2SLC1A1MEN1
SCHEMBL1143117 0.80 LMNA (0.41) LMNASLC1A3SLC1A2SLC1A1NAAA
SCHEMBL10072107 0.78 LMNA (0.42) LMNASLC1A3SLC1A2SLC1A1KMT2A
SCHEMBL1143120 0.78 LMNA (0.38) LMNASLC1A3SLC1A2SLC1A1NAAA
SCHEMBL3821994 0.78 EPHX1 (0.40) LMNASLC1A3SLC1A2SLC1A1MEN1
SCHEMBL1143159 0.77 LMNA (0.42) LMNASLC1A3SLC1A2SLC1A1NAAA
SCHEMBL14975446 0.77
SCHEMBL1142659 0.76 SLC1A3 (0.38) LMNASLC1A3SLC1A2SLC1A1NAAA
SCHEMBL14975548 0.76
SCHEMBL13979022 0.76 EPHX1 (0.42) KMT2AEPHX1HPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3204159-B1 PROCESS FOR PREPARING SPHERICAL POLYMERIZATION CATALYST COMPONENTS FOR USE IN OLEFIN POLYMERIZATIONS GRACE W R & CO (US) 2020-12-16 EP disclosed
EP-2701843-B1 EMULSION PROCESS FOR IMPROVED LARGE SPHERICAL POLYPROPYLENE CATALYSTS W R GRACE & CO -CONN (US) 2017-11-29 EP disclosed
US-9714302-B2 Process for preparing spherical polymerization catalyst components for use in olefin polymerizations W. R. Grace & Co.—Conn. (US) 2017-07-25 US disclosed
US-9403924-B2 Process of production of large and spherical polymerization catalyst and use of same in olefin polymerizations BASF CORPORATION (US) 2016-08-02 US disclosed
US-20150361194-A1 PROCESS OF PRODUCTION OF LARGE AND SPHERICAL POLYMERIZATION CATALYST AND USE OF SAME IN OLEFIN POLYMERIZATIONS W. R. GRACE & CO.-CONN. 2015-12-17 US disclosed
EP-2782938-A1 HIGH ACTIVITY CATALYST COMPONENT FOR OLEFIN POLYMERIZATION AND METHOD OF USING THE SAME BASF Corporation (US) 2014-10-01 EP disclosed
US-8569195-B2 Internal and external donor compounds for olefin polymerization catalysts II BASF CORPORATION (US) 2013-10-29 US disclosed
WO-2013077837-A1 HIGH ACTIVITY CATALYST COMPONENT FOR OLEFIN POLYMERIZATION AND METHOD OF USING THE SAME BASF CORPORATION (US) 2013-05-30 WO disclosed
US-20110207901-A1 INTERNAL AND EXTERNAL DONOR COMPOUNDS FOR OLEFIN POLYMERIZATION CATALYSTS II BASF CATALYSTS LLC (US) 2011-08-25 US disclosed
US-8003559-B2 Internal donor for olefin polymerization catalysts BASF CORPORATION (US) 2011-08-23 US disclosed
US-20110034651-A1 MIXED DONOR SYSTEM FOR HIGH MELT FLOW AND HIGH ACTIVITY BASF CATALYSTS LLC (US) 2011-02-10 US disclosed
US-20090286672-A1 INTERNAL DONOR FOR OLEFIN POLYMERIZATION CATALYSTS BASF CATALYSTS LLC (US) 2009-11-19 US disclosed