Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | NPC1 | O15118 | 1/20 | 0.54 |
| ▸ | RAB9A | P51151 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | GAA | P10253 | 3/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.44 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.44 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.44 |
| ▸ | GPR139 | Q6DWJ6 | 1/20 | 0.44 |
| ▸ | ITGAV | P06756 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | F10 | P00742 | 1/20 | 0.44 |
| ▸ | BACE1 | P56817 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1143015 | 1.00 | SMN1; SMN2 (0.54) | SMN1; SMN2NPC1RAB9AKMT2AGAA | |
| SCHEMBL3655886 | 1.00 | SMN1; SMN2 (0.54) | SMN1; SMN2NPC1RAB9AKMT2AGAA | |
| SCHEMBL12082412 | 1.00 | SMN1; SMN2 (0.54) | SMN1; SMN2NPC1RAB9AKMT2AGAA | |
| SCHEMBL1143640 | 1.00 | SMN1; SMN2 (0.54) | SMN1; SMN2NPC1RAB9AKMT2AGAA | |
| SCHEMBL15492571 | 1.00 | SMN1; SMN2 (0.54) | SMN1; SMN2NPC1RAB9AKMT2AGAA | |
| SCHEMBL2318986 | 0.88 | SMN1; SMN2 (0.51) | SMN1; SMN2NPC1RAB9AKMT2AGAA | |
| SCHEMBL9132043 | 0.88 | SMN1; SMN2 (0.51) | SMN1; SMN2NPC1RAB9AKMT2AGAA | |
| SCHEMBL9132593 | 0.88 | SMN1; SMN2 (0.51) | SMN1; SMN2NPC1RAB9AKMT2AGAA | |
| SCHEMBL2319093 | 0.88 | SMN1; SMN2 (0.51) | SMN1; SMN2NPC1RAB9AKMT2AGAA | |
| SCHEMBL2322450 | 0.86 | NPC1 (0.49) | SMN1; SMN2NPC1RAB9AKMT2AGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 73 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118685378-A | Carbonyl reductase mutant and application thereof in synthesis of 4-AA chiral intermediate | 福州大学 | 2024-09-24 | — | — | CN | claimed |
| CN-115433721-B | Carbonyl reductase mutant and application thereof | 山东理工大学 | 2024-01-23 | — | — | CN | claimed |
| CN-115433721-A | Carbonyl reductase mutant and application thereof | 山东理工大学 | 2022-12-06 | — | — | CN | claimed |
| US-9382519-B2 | Ketoreductase polypeptides for the production of azetidinone | CODEXIS, INC. (US) | 2016-07-05 | — | — | US | claimed |
| EP-2205727-B1 | KETOREDUCTASE POLYPEPTIDES FOR THE PRODUCTION OF AZETIDINONE | CODEXIS INC (US) | 2015-06-24 | — | — | EP | claimed |
| US-7883879-B2 | Ketoreductase polypeptides for the production of azetidinone | CODEXIS, INC. (US) | 2011-02-08 | — | — | US | claimed |
| EP-2205727-A1 | KETOREDUCTASE POLYPEPTIDES FOR THE PRODUCTION OF AZETIDINONE | Codexis, Inc. (US) | 2010-07-14 | — | — | EP | claimed |
| US-20090162909-A1 | Ketoreductase Polypeptides for the Production of Azetidinone | CODEXIS, INC. (US) | 2009-06-25 | — | — | US | claimed |
| WO-2009046153-A1 | KETOREDUCTASE POLYPEPTIDES FOR THE PRODUCTION OF AZETIDINONE | CODEXIS, INC. (US) | 2009-04-09 | — | — | WO | claimed |
| CN-118685378-B | Carbonyl reductase mutant and application thereof in synthesis of 4-AA chiral intermediate | 福州大学 | 2025-10-28 | — | — | CN | disclosed |
| US-12421503-B2 | Ketoreductase polypeptides for the production of azetidinone | CODEXIS, INC. (US) | 2025-09-23 | — | — | US | disclosed |
| CN-119776301-A | Alcohol dehydrogenase, recombinant genetically engineered bacterium and application thereof in asymmetric reduction of potential chiral carbonyl compounds | 杭州文德阶生物科技有限公司 | 2025-04-08 | — | — | CN | disclosed |
| CN-119614529-A | Short-chain dehydrogenase, engineering bacteria and application thereof in asymmetric reduction of potential chiral carbonyl compounds | 杭州文德阶生物科技有限公司 | 2025-03-14 | — | — | CN | disclosed |
| CN-118685378-A | Carbonyl reductase mutant and application thereof in synthesis of 4-AA chiral intermediate | 福州大学 | 2024-09-24 | — | — | CN | disclosed |
| US-7883879-B2 | Ketoreductase polypeptides for the production of azetidinone | CODEXIS, INC. (US) | 2011-02-08 | — | — | US | disclosed |
| US-7883879-B2 | Ketoreductase polypeptides for the production of azetidinone | CODEXIS, INC. (US) | 2011-02-08 | — | — | US | disclosed |
| EP-2205727-A1 | KETOREDUCTASE POLYPEPTIDES FOR THE PRODUCTION OF AZETIDINONE | Codexis, Inc. (US) | 2010-07-14 | — | — | EP | disclosed |
| US-20090162909-A1 | Ketoreductase Polypeptides for the Production of Azetidinone | CODEXIS, INC. (US) | 2009-06-25 | — | — | US | disclosed |
| US-20090162909-A1 | Ketoreductase Polypeptides for the Production of Azetidinone | CODEXIS, INC. (US) | 2009-06-25 | — | — | US | disclosed |
| WO-2009046153-A1 | KETOREDUCTASE POLYPEPTIDES FOR THE PRODUCTION OF AZETIDINONE | CODEXIS, INC. (US) | 2009-04-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090162909-A1 | Ketoreductase Polypeptides for the Production of Azetidinone | AKR1B10, AKR1A1, AKR1C2 | SMN1; SMN2 3133/4885NPC1 2100/4885RAB9A 4777/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.