Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.58 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.58 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.55 |
| ▸ | CES2 | O00748 | 2/20 | 0.50 |
| ▸ | CES1 | P23141 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.42 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.42 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.42 |
| ▸ | HTR1F | P30939 | 1/20 | 0.42 |
| ▸ | MGLL | Q99685 | 2/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.41 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.41 |
| ▸ | HTR3B | O95264 | 1/20 | 0.41 |
| ▸ | HTR3A | P46098 | 1/20 | 0.41 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.41 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21448795 | 0.89 | HSD11B1 (0.60) | MEN1KMT2ACYP2D6HSD11B1CES2 | |
| SCHEMBL4671166 | 0.85 | MEN1 (0.62) | MEN1KMT2ACYP2D6HSD11B1ALDH1A1 | |
| SCHEMBL27818194 | 0.84 | HSD11B1 (0.56) | HSD11B1CES2CES1ALDH1A1LMNA | |
| Hydrochloric Acid SCHEMBL30951271 | 0.84 | MEN1 (0.56) | MEN1KMT2ACYP2D6HSD11B1ALDH1A1 | |
| SCHEMBL14508411 | 0.83 | HSD11B1 (0.46) | MEN1KMT2ACYP2D6HSD11B1CES2 | |
| SCHEMBL228259 | 0.82 | MEN1 (0.67) | MEN1KMT2ACYP2D6HSD11B1MGLL | |
| Hydrochloric Acid SCHEMBL5478832 | 0.82 | HSD11B1 (0.45) | MEN1KMT2ACYP2D6HSD11B1CES2 | |
| Hydrochloric Acid SCHEMBL5478835 | 0.82 | HSD11B1 (0.45) | MEN1KMT2ACYP2D6HSD11B1CES2 | |
| SCHEMBL16442371 | 0.82 | HTT (0.56) | MEN1KMT2ACYP2D6ALDH1A1LMNA | |
| SCHEMBL16861656 | 0.81 | ALDH1A1 (0.55) | MEN1KMT2ACYP2D6HSD11B1CES2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8598179-B2 | Pyrazole-carboxamide derivatives as P2Y12 antagonists | SANOFI (FR) | 2013-12-03 | — | — | US | disclosed |
| EP-2238127-B1 | PYRAZOLE-CARBOXAMIDE DERIVATIVES AS P2Y12 ANTAGONISTS | SANOFI SA (FR) | 2012-08-15 | — | — | EP | disclosed |
| US-20110039829-A1 | PYRAZOLE-CARBOXAMIDE DERIVATIVES AS P2Y12 ANTAGONISTS | SANOFI-AVENTIS (FR) | 2011-02-17 | — | — | US | disclosed |
| EP-2238127-A2 | PYRAZOLE-CARBOXAMIDE DERIVATIVES AS P2Y12 ANTAGONISTS | Sanofi-Aventis (FR) | 2010-10-13 | — | — | EP | disclosed |
| WO-2009080227-A2 | PYRAZOLE-CARBOXAMIDE DERIVATIVES AS P2Y12 ANTAGONISTS | SANOFI-AVENTIS (FR) | 2009-07-02 | — | — | WO | disclosed |
| US-5541201-A | Antiarrhythmic piperidin-1-yl-2,2-dialkylpropanone arylsulfonamide derivatives | MERRELL PHARMACEUTICALS, INC. (US) | 1996-07-30 | — | — | US | disclosed |
| WO-1995000481-A1 | PIPERIDIN-1-YL-2,2-DIALKYLPROPANONEARYLSULFONAMIDE DERIVATIVES | MERRELL DOW PHARMACEUTICALS INC. (US) | 1995-01-05 | — | — | WO | disclosed |
| US-5198449-A | N-substituted alpha-arylazacycloalkylmethanamines and their use as cardiovascular agents | A. H. ROBINS COMPANY INCORPORATED (US) | 1993-03-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110039829-A1 | PYRAZOLE-CARBOXAMIDE DERIVATIVES AS P2Y12 ANTAGONISTS | P2RY1, P2RY12, P2RY11 | MEN1 2933/4885KMT2A 2902/4885CYP2D6 1427/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.