Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 2/20 | 0.41 |
| ▸ | MME | P08473 | 1/20 | 0.40 |
| ▸ | ECE1 | P42892 | 1/20 | 0.40 |
| ▸ | FNTA | P49354 | 1/20 | 0.40 |
| ▸ | FNTB | P49356 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | HRAS | P01112 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11437514 | 0.82 | CTSL (0.40) | ALDH1A1MAPK1L3MBTL1 | |
| SCHEMBL11419458 | 0.78 | ITGB2 (0.54) | RENMMEECE1ALDH1A1 | |
| SCHEMBL11416854 | 0.76 | CYP3A4 (0.50) | — | |
| SCHEMBL11411181 | 0.74 | CTSL (0.39) | ALDH1A1MAPK1L3MBTL1 | |
| SCHEMBL11411177 | 0.74 | CTSL (0.39) | ALDH1A1MAPK1L3MBTL1 | |
| SCHEMBL11417429 | 0.72 | ACE (0.43) | ALDH1A1MAPK1L3MBTL1 | |
| SCHEMBL11419443 | 0.71 | ALDH1A1 (0.63) | RENMMEALDH1A1 | |
| SCHEMBL6153746 | 0.71 | GAA (0.52) | ALDH1A1MAPK1L3MBTL1 | |
| SCHEMBL26304185 | 0.70 | ALDH1A1 (0.57) | ALDH1A1 | |
| SCHEMBL11424459 | 0.70 | ALDH1A1 (0.58) | RENMMEALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4228184-A | HYPOTENSIVE AGENTS | E. R. SQUIBB & SONS, INC. (US) | 1980-10-14 | — | — | US | disclosed |
| US-4207336-A | AGIOTENSIN RELATED HYPERTENSION | E. R. SQUIBB & SONS, INC. (US) | 1980-06-10 | — | — | US | disclosed |
| US-4207342-A | Relieving hypertension with carboxyalkylacylamino acids | E. R. SQUIBB & SONS, INC. (US) | 1980-06-10 | — | — | US | disclosed |
| US-4207337-A | ESPECIALLY ANGIOTENSIN RELATED HYPERTENSION | E. R. SQUIBB & SONS, INC. (US) | 1980-06-10 | — | — | US | disclosed |
| US-4206232-A | Relieving hypertension with carboxyalkylacylamino acids | E. R. SQUIBB & SONS, INC. (US) | 1980-06-03 | — | — | US | disclosed |
| US-4200649-A | Relieving hypertension with carboxyalkylacylamino acids | E. R. SQUIBB & SONS, INC. (US) | 1980-04-29 | — | — | US | disclosed |
| US-4192881-A | RELIEVING ANGIOTENSIN RELATED HYPERTENSION | E. R. SQUIBB & SONS, INC. (US) | 1980-03-11 | — | — | US | disclosed |
| US-4153725-A | ANGIOTENSIN CONVERTING ENZYME INHIBITORS | E. R. SQUIBB & SONS, INC. (US) | 1979-05-08 | — | — | US | disclosed |
| US-4146641-A | ANGIOTENSIN CONVERTING ENZYME INHIBITORS | E. R. SQUIBB & SONS, INC. (US) | 1979-03-27 | — | — | US | disclosed |
| US-4146639-A | ANGIOTENSIN CONVERTING ENZYME INHIBITORS | E. R. SQUIBB & SONS, INC. (US) | 1979-03-27 | — | — | US | disclosed |
| US-4105789-A | Carboxyalkylacylamino acids | E. R. SQUIBB & SONS, INC. (US) | 1978-08-08 | — | — | US | disclosed |