Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APEX1 | P27695 | 1/20 | 0.61 |
| ▸ | NT5E | P21589 | 3/20 | 0.45 |
| ▸ | CASP6 | P55212 | 2/20 | 0.44 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | ENPP2 | Q13822 | 2/20 | 0.39 |
| ▸ | TIMP3 | P35625 | 1/20 | 0.37 |
| ▸ | PTPN11 | Q06124 | 2/20 | 0.37 |
| ▸ | NSD2 | O96028 | 1/20 | 0.37 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.37 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | CD40 | P25942 | 1/20 | 0.36 |
| ▸ | CD40LG | P29965 | 1/20 | 0.36 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11438353 | 0.99 | APEX1 (0.60) | APEX1NT5ECASP6CTDSP1POLB | |
| SCHEMBL11432619 | 0.89 | APEX1 (0.46) | APEX1CASP6CTDSP1POLBMAPT | |
| SCHEMBL11429045 | 0.85 | POLB (0.57) | APEX1POLBMAPTGAAPTPN11 | |
| SCHEMBL11429040 | 0.84 | POLB (0.56) | APEX1POLBMAPTGAAPTPN11 | |
| SCHEMBL11589917 | 0.81 | APEX1 (0.77) | APEX1NT5ECASP6CTDSP1POLB | |
| SCHEMBL6560534 | 0.81 | APEX1 (0.77) | APEX1NT5ECASP6CTDSP1POLB | |
| SCHEMBL5567709 | 0.81 | APEX1 (0.76) | APEX1NT5ECASP6CTDSP1MAPT | |
| SCHEMBL11436257 | 0.80 | APEX1 (0.53) | APEX1NT5ECASP6CTDSP1POLB | |
| SCHEMBL11597795 | 0.79 | APEX1 (0.69) | APEX1NT5ECASP6CTDSP1POLB | |
| SCHEMBL11597004 | 0.78 | APEX1 (0.72) | APEX1CASP6CTDSP1POLBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4229584-A | Ureylenebis(anionic substituted phenylene carbonyl)imino naphthalene sulfonic acids and naphthalene carboxylic acids and their salts | AMERICAN CYANAMID COMPANY (US) | 1980-10-21 | — | — | US | disclosed |
| US-4177209-A | COMPLEMENT INHIBITORS | AMERICAN CYANAMID COMPANY (US) | 1979-12-04 | — | — | US | disclosed |
| US-4129590-A | INHIBITORS OF THE COMPLEMENT SYSTEM | AMERICAN CYANAMID COMPANY (US) | 1978-12-12 | — | — | US | disclosed |