Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | APEX1 | P27695 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 8/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | HPGD | P15428 | 3/20 | 0.50 |
| ▸ | CASP3 | P42574 | 2/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | AHR | P35869 | 1/20 | 0.43 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.42 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.42 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11429045 | 0.99 | POLB (0.57) | POLBAPEX1MEN1KMT2AALDH1A1 | |
| SCHEMBL11597984 | 0.92 | APEX1 (0.65) | POLBAPEX1MEN1KMT2AALDH1A1 | |
| SCHEMBL11438353 | 0.85 | APEX1 (0.60) | POLBAPEX1MEN1KMT2AALDH1A1 | |
| SCHEMBL11438401 | 0.84 | APEX1 (0.61) | POLBAPEX1MEN1KMT2AALDH1A1 | |
| SCHEMBL8755454 | 0.82 | APEX1 (0.70) | APEX1MEN1KMT2AALDH1A1MAPT | |
| SCHEMBL10412672 | 0.81 | APEX1 (0.69) | POLBAPEX1MEN1KMT2AALDH1A1 | |
| SCHEMBL11424495 | 0.81 | APEX1 (0.49) | POLBAPEX1MEN1KMT2AALDH1A1 | |
| SCHEMBL11407259 | 0.78 | TIMP3 (0.55) | POLBMEN1KMT2AALDH1A1MAPT | |
| SCHEMBL11425899 | 0.77 | TIMP3 (0.56) | POLBMEN1KMT2AALDH1A1MAPT | |
| Lindane SCHEMBL11436245 | 0.76 | APEX1 (0.45) | POLBAPEX1MEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4229584-A | Ureylenebis(anionic substituted phenylene carbonyl)imino naphthalene sulfonic acids and naphthalene carboxylic acids and their salts | AMERICAN CYANAMID COMPANY (US) | 1980-10-21 | — | — | US | disclosed |
| US-4177209-A | COMPLEMENT INHIBITORS | AMERICAN CYANAMID COMPANY (US) | 1979-12-04 | — | — | US | disclosed |
| US-4129590-A | INHIBITORS OF THE COMPLEMENT SYSTEM | AMERICAN CYANAMID COMPANY (US) | 1978-12-12 | — | — | US | disclosed |