SCHEMBL11438751

SCHEMBL11438751

C/C=C\c1ccc(Cl)cc1

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
AHR P35869 1/20 0.54
LMNA P02545 3/20 0.52
ALDH1A1 P00352 2/20 0.52
TP53 P04637 1/20 0.52
CYP3A4 P08684 1/20 0.52
TSHR P16473 1/20 0.52
KDM4E B2RXH2 1/20 0.52
CYP1A2 P05177 1/20 0.50
ALOX5 P09917 1/20 0.48
PTGS1 P23219 1/20 0.48
PTGS2 P35354 1/20 0.48
HSD17B10 Q99714 1/20 0.48
FBP1 P09467 1/20 0.46
CYP2A6 P11509 1/20 0.44
NFE2L2 Q16236 1/20 0.43
CNR2 P34972 1/20 0.43
MAOB P27338 2/20 0.42
MAOA P21397 1/20 0.42
NPC1 O15118 1/20 0.42
MAPT P10636 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1425165 1.00 AHR (0.54) AHRLMNAALDH1A1TP53CYP3A4
SCHEMBL432740 1.00 AHR (0.54) AHRLMNAALDH1A1TP53CYP3A4
SCHEMBL333123 0.85 CYP3A4 (0.65) LMNAALDH1A1TP53CYP3A4TSHR
SCHEMBL9461723 0.85 CYP3A4 (0.65) LMNAALDH1A1TP53CYP3A4TSHR
SCHEMBL7527708 0.85 CYP3A4 (0.65) LMNAALDH1A1TP53CYP3A4TSHR
SCHEMBL699666 0.82 AHR (0.74) AHRLMNAALDH1A1KDM4ECYP1A2
SCHEMBL1795502 0.82 AHR (0.74) AHRLMNAALDH1A1KDM4ECYP1A2
SCHEMBL9679426 0.82 AHR (0.74) AHRLMNAALDH1A1KDM4ECYP1A2
SCHEMBL20582895 0.82 AHR (0.74) AHRLMNAALDH1A1KDM4ECYP1A2
SCHEMBL9679429 0.82 AHR (0.74) AHRLMNAALDH1A1KDM4ECYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4273129-A1 RORgammaT MODULATOR, AND PREPARATION METHOD THEREFOR AND APPLICATION THEREOF Shanghai Pharmaceuticals Holding Co., Ltd. (CN) 2023-11-08 EP disclosed
WO-2011069039-A1 HYDRAZONE AND DIACYL HYDRAZINE COMPOUNDS AND METHODS OF USE THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) 2011-06-09 WO disclosed
EP-0018144-A1 A process for the preparation of substituted 2-aminopyrazines ELI LILLY AND COMPANY (US) 1980-10-29 EP disclosed
EP-0017494-A2 Hydroxyimino-substituted aminoacetonitrile intermediates and their preparation ELI LILLY AND COMPANY (US) 1980-10-15 EP disclosed
US-4211870-A FROM AMINOACETONITRILE AND A PHENYL A-HALO OXIME ELI LILLY AND COMPANY (US) 1980-07-08 US disclosed
US-4199525-A Hydroxyimino-substituted aminoacetonitriles ELI LILLY AND COMPANY (US) 1980-04-22 US disclosed