SCHEMBL432740

SCHEMBL432740

C/C=C/c1ccc(Cl)cc1

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
AHR P35869 1/20 0.54
LMNA P02545 3/20 0.52
ALDH1A1 P00352 2/20 0.52
TP53 P04637 1/20 0.52
CYP3A4 P08684 1/20 0.52
TSHR P16473 1/20 0.52
KDM4E B2RXH2 1/20 0.52
CYP1A2 P05177 1/20 0.50
ALOX5 P09917 1/20 0.48
PTGS1 P23219 1/20 0.48
PTGS2 P35354 1/20 0.48
HSD17B10 Q99714 1/20 0.48
FBP1 P09467 1/20 0.46
CYP2A6 P11509 1/20 0.44
NFE2L2 Q16236 1/20 0.43
CNR2 P34972 1/20 0.43
MAOB P27338 2/20 0.42
MAOA P21397 1/20 0.42
NPC1 O15118 1/20 0.42
MAPT P10636 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1425165 1.00 AHR (0.54) AHRLMNAALDH1A1TP53CYP3A4
SCHEMBL11438751 1.00 AHR (0.54) AHRLMNAALDH1A1TP53CYP3A4
SCHEMBL333123 0.85 CYP3A4 (0.65) LMNAALDH1A1TP53CYP3A4TSHR
SCHEMBL9461723 0.85 CYP3A4 (0.65) LMNAALDH1A1TP53CYP3A4TSHR
SCHEMBL7527708 0.85 CYP3A4 (0.65) LMNAALDH1A1TP53CYP3A4TSHR
SCHEMBL699666 0.82 AHR (0.74) AHRLMNAALDH1A1KDM4ECYP1A2
SCHEMBL1795502 0.82 AHR (0.74) AHRLMNAALDH1A1KDM4ECYP1A2
SCHEMBL9679426 0.82 AHR (0.74) AHRLMNAALDH1A1KDM4ECYP1A2
SCHEMBL20582895 0.82 AHR (0.74) AHRLMNAALDH1A1KDM4ECYP1A2
SCHEMBL9679429 0.82 AHR (0.74) AHRLMNAALDH1A1KDM4ECYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 154 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3720861-A1 CHEMICAL PROCESS FOR THE SYNTHESIS OF HERBICIDAL PYRAZOLIDINEDIONE COMPOUNDS Syngenta Participations AG (CH) 2020-10-14 EP claimed
WO-2019110613-A1 CHEMICAL PROCESS FOR THE SYNTHESIS OF HERBICIDAL PYRAZOLIDINEDIONE COMPOUNDS SYNGENTA PARTICIPATIONS AG (CH) 2019-06-13 WO claimed
US-4956123-A REACTING A STYRENE TYPE COMPOUND WITH A DIHALOACYL PEROXIDE TO MAKE A FLUOROALKYLAROMATIC ESTER NIPPON OILS & FATS COMPANY, LTD. (JP) 1990-09-11 US claimed
CN-118930392-A Aldehyde deoxidization and reduction method 温州医科大学 2024-11-12 CN disclosed
US-20230354808-A1 METHOD OF CONTROLLING SOYBEAN RUST FUNGUS RESISTANT TO QOI FUNGICIDE SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2023-11-09 US disclosed
US-20230357164-A1 NOVEL QUINAZOLINE DERIVATIVE HAVING FLT3 INHIBITORY ACTIVITY, AND USE THEREOF INDUSTRY-UNIVERSITY COOPERATION FOUNDATION HANYANG UNIVERSITY ERICA CAMPUS (KR) 2023-11-09 US disclosed
US-20230354808-A1 METHOD OF CONTROLLING SOYBEAN RUST FUNGUS RESISTANT TO QOI FUNGICIDE SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2023-11-09 US disclosed
US-20230357164-A1 NOVEL QUINAZOLINE DERIVATIVE HAVING FLT3 INHIBITORY ACTIVITY, AND USE THEREOF INDUSTRY-UNIVERSITY COOPERATION FOUNDATION HANYANG UNIVERSITY ERICA CAMPUS (KR) 2023-11-09 US disclosed
EP-4234536-A2 AMINO-ARYL-BENZAMIDE COMPOUNDS AND METHODS OF USE THEREOF Hepanova, Inc. (US) 2023-08-30 EP disclosed
WO-2023275052-A1 BUFALIN DERIVATIVES USEFUL IN THERAPY VESTLANDETS INNOVASJONSSELSKAP AS (NO) 2023-01-05 WO disclosed
CN-110903231-B 2-cyanopyrrole compounds and synthesis method thereof 上海大学 2022-11-08 CN disclosed
EP-0791024-A1 PIGMENT DISPERSING ADDITIVE FOR COATING COMPOSITIONS PPG INDUSTRIES, INC. (US) 1997-08-27 EP disclosed
US-5612416-A PROTECTIVE COATINGS FORMED FROM HYDROXY GROUP REACTIVE CURING AGENTS PPG INDUSTRIES, INC. (US) 1997-03-18 US disclosed
WO-1997001602-A1 METHOD OF PREPARING INORGANIC PIGMENT DISPERSIONS HENKEL CORPORATION (US) 1997-01-16 WO disclosed
US-5585427-A COPOLYMER WITH AN ACID VALUE LESS THAN ONE CONTAINING ALTERNATING UNITS OF A VINYL MONOMER AND A DIESTER OF A DICARBOXYLIC ACID WHEREIN AT LEAST ONE OF THE ESTERIFYING GROUPS CONTAINS A POLYETHER GROUP PPG INDUSTRIES, INC. (US) 1996-12-17 US disclosed
WO-1996014347-A1 PIGMENT DISPERSING ADDITIVE FOR COATING COMPOSITIONS PPG INDUSTRIES, INC. (US) 1996-05-17 WO disclosed
US-4956123-A REACTING A STYRENE TYPE COMPOUND WITH A DIHALOACYL PEROXIDE TO MAKE A FLUOROALKYLAROMATIC ESTER NIPPON OILS & FATS COMPANY, LTD. (JP) 1990-09-11 US disclosed
EP-0189275-B1 METHOD FOR MANUFACTURE OF FLUORINE-CONTAINING AROMATIC DERIVATIVES NIPPON OIL AND FATS COMPANY, LIMITED (JP) 1989-10-18 EP disclosed
EP-0104863-B1 LIGHT-SENSITIVE PLANOGRAPHIC PRINTING PLATE FUJI PHOTO FILM CO., LTD. (JP) 1989-05-03 EP disclosed
EP-0189275-A2 Method for manufacture of fluorine-containing aromatic derivatives NIPPON OIL AND FATS COMPANY, LIMITED (JP) 1986-07-30 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230354808-A1 METHOD OF CONTROLLING SOYBEAN RUST FUNGUS RESISTANT TO QOI FUNGICIDE SQOR, CYC1, COX5B AHR 92/4885LMNA 2839/4885ALDH1A1 4194/4885
US-20230357164-A1 NOVEL QUINAZOLINE DERIVATIVE HAVING FLT3 INHIBITORY ACTIVITY, AND USE THEREOF FLT3, ABL1, MCL1 AHR 3309/4885LMNA 4518/4885ALDH1A1 3264/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.