Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.45 |
| ▸ | SLC1A3 | P43003 | 4/20 | 0.41 |
| ▸ | SLC1A2 | P43004 | 4/20 | 0.41 |
| ▸ | SLC1A1 | P43005 | 3/20 | 0.41 |
| ▸ | GRIK1 | P39086 | 7/20 | 0.41 |
| ▸ | GRIA4 | P48058 | 3/20 | 0.41 |
| ▸ | GRIK3 | Q13003 | 3/20 | 0.41 |
| ▸ | GRIK5 | Q16478 | 3/20 | 0.41 |
| ▸ | GRIK2 | Q13002 | 3/20 | 0.41 |
| ▸ | GRIA2 | P42262 | 2/20 | 0.41 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.41 |
| ▸ | ECE1 | P42892 | 1/20 | 0.40 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.39 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.38 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.38 |
| ▸ | REN | P00797 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10596071 | 0.82 | FOLH1 (0.48) | SLC7A5SLC1A3SLC1A2SLC1A1GRIK1 | |
| SCHEMBL9684668 | 0.82 | FOLH1 (0.48) | SLC7A5SLC1A3SLC1A2SLC1A1GRIK1 | |
| SCHEMBL11417051 | 0.78 | SLC1A1 (0.49) | SLC7A5SLC1A3SLC1A2SLC1A1GRIK1 | |
| SCHEMBL18098574 | 0.76 | SLC7A5 (0.52) | SLC7A5SLC1A3SLC1A2SLC1A1GRIK1 | |
| SCHEMBL24603278 | 0.76 | SLC7A5 (0.52) | SLC7A5SLC1A3SLC1A2SLC1A1GRIK1 | |
| SCHEMBL11417587 | 0.74 | GRM8 (0.46) | SLC1A3SLC1A2SLC1A1GRIK1GRIA4 | |
| SCHEMBL21585639 | 0.73 | SLC7A5 (0.58) | SLC7A5SLC1A3SLC1A2SLC1A1GRIK1 | |
| SCHEMBL434918 | 0.73 | SLC7A5 (0.58) | SLC7A5SLC1A3SLC1A2SLC1A1GRIK1 | |
| SCHEMBL21577845 | 0.73 | SLC7A5 (0.58) | SLC7A5SLC1A3SLC1A2SLC1A1GRIK1 | |
| SCHEMBL21690060 | 0.73 | SLC7A5 (0.58) | SLC7A5SLC1A3SLC1A2SLC1A1GRIK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4228184-A | HYPOTENSIVE AGENTS | E. R. SQUIBB & SONS, INC. (US) | 1980-10-14 | — | — | US | disclosed |
| US-4207336-A | AGIOTENSIN RELATED HYPERTENSION | E. R. SQUIBB & SONS, INC. (US) | 1980-06-10 | — | — | US | disclosed |
| US-4207337-A | ESPECIALLY ANGIOTENSIN RELATED HYPERTENSION | E. R. SQUIBB & SONS, INC. (US) | 1980-06-10 | — | — | US | disclosed |
| US-4206232-A | Relieving hypertension with carboxyalkylacylamino acids | E. R. SQUIBB & SONS, INC. (US) | 1980-06-03 | — | — | US | disclosed |
| US-4200649-A | Relieving hypertension with carboxyalkylacylamino acids | E. R. SQUIBB & SONS, INC. (US) | 1980-04-29 | — | — | US | disclosed |
| US-4153725-A | ANGIOTENSIN CONVERTING ENZYME INHIBITORS | E. R. SQUIBB & SONS, INC. (US) | 1979-05-08 | — | — | US | disclosed |
| US-4146639-A | ANGIOTENSIN CONVERTING ENZYME INHIBITORS | E. R. SQUIBB & SONS, INC. (US) | 1979-03-27 | — | — | US | disclosed |
| US-4146641-A | ANGIOTENSIN CONVERTING ENZYME INHIBITORS | E. R. SQUIBB & SONS, INC. (US) | 1979-03-27 | — | — | US | disclosed |