Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 3/20 | 0.53 |
| ▸ | TYK2 | P29597 | 3/20 | 0.53 |
| ▸ | JAK1 | P23458 | 3/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.49 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.49 |
| ▸ | PPIA | P62937 | 1/20 | 0.49 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.49 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.49 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | APAF1 | O14727 | 1/20 | 0.45 |
| ▸ | TDP2 | O95551 | 1/20 | 0.45 |
| ▸ | NSD2 | O96028 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11499405 | 0.87 | GAA (0.59) | JAK2TYK2JAK1KMT2AMAPT | |
| SCHEMBL8668403 | 0.84 | MAPT (0.47) | JAK2TYK2JAK1CYP3A4KMT2A | |
| Hydrochloric Acid SCHEMBL7942179 | 0.82 | MAPT (0.46) | JAK2TYK2JAK1CYP3A4KMT2A | |
| SCHEMBL16059203 | 0.79 | JAK2 (0.57) | JAK2JAK1KMT2AALDH1A1CYP1A2 | |
| SCHEMBL5467789 | 0.79 | KDM4E (0.65) | JAK2TYK2JAK1CYP3A4KMT2A | |
| SCHEMBL4377125 | 0.78 | ALDH1A1 (0.56) | JAK2TYK2JAK1CYP3A4KMT2A | |
| SCHEMBL9118696 | 0.78 | POLB (0.64) | JAK2TYK2KMT2AALDH1A1CYP1A2 | |
| SCHEMBL20387809 | 0.76 | ALDH1A1 (0.50) | JAK2TYK2JAK1CYP3A4ALDH1A1 | |
| Urea SCHEMBL10392049 | 0.76 | KMT2A (0.56) | JAK2TYK2JAK1CYP3A4KMT2A | |
| SCHEMBL11005407 | 0.76 | ALDH1A1 (0.56) | JAK2TYK2JAK1CYP3A4KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0018144-A1 | A process for the preparation of substituted 2-aminopyrazines | ELI LILLY AND COMPANY (US) | 1980-10-29 | — | — | EP | disclosed |
| US-4211870-A | FROM AMINOACETONITRILE AND A PHENYL A-HALO OXIME | ELI LILLY AND COMPANY (US) | 1980-07-08 | — | — | US | disclosed |
| US-4164581-A | 1-(2,6-Dichlorobenzoyl)-3-(4-trifluoromethyl-2-thiazolyl)urea and use as insecticide | GULF OIL CORPORATION (US) | 1979-08-14 | — | — | US | disclosed |